Ganoderma against cancer of the initial pre-clinical efficacy assessment

Ganoderma against cancer of the initial pre-clinical efficacy assessment

Pre-clinical effects of Ganoderma lucidum on cancer treatment

Cancer is a major world medical issues, there is no effective treatment to

eradicate cancer cells, rather the herbs used in cancer therapy is currently one of the emerging research directions. The scientific name Ganoderma lucidum Ganoderma lucidum, is a woody fungus burden, has been studied proved to be an immediate cytotoxic and can inhibit the growth of various cancer cells. ^{The study}

is in the human HeLa cervical cancer cells and non-small cell lung cancer H441GL as cancer of the model of alcohol extracts of Ganoderma lucidum inhibited the effect and mechanism of cancer, while use of the laboratory to detect reversal of cancer screening platform technology, further study whether the alcohol extracts of Ganoderma lucidum and inhibit the malignant characteristics of cancer and reversed, and the use of non-invasive in vivo molecular genetic imaging system synchronization immediately observe cancer cells in vivo biological variation.

The first part of the experiment, alcohol extracts of Ganoderma lucidum treatment of human cervical cancer HeLa, showed that alcohol extracts of Ganoderma lucidum could inhibit the HeLa cervical cancer cells alkaline phosphatase(Alkline phosphates) performance characteristics with the reversal of cancer, and cell growth inhibition, cell cycle in sub-G1 phase significantly increased percentage of cells and apoptosis in cancer precursor protein E7 protein procaspase 3

expression decreased ability of cell migration was inhibited. Tumor formation in vivo experiments, long-term feeding alcohol extracts of Ganoderma lucidum 1000 mg / kg / mice / day can inhibit tumor cell formation in experimental animals.

The second part of the results showed that alcohol extracts of Ganoderma lucidum could inhibit the growth of human lung cancer cells H441GL, with the increase of drug concentration expression of cyclin E protein increased, so that cell cycle arrest in G0/G1 phase, additional capacity will decrease as cell migration . In animal experiments, long-term alcohol extracts of Ganoderma lucidum to 1000 mg / kg / mice / daycan inhibit tumor formation ability H441GL.

This study showed that alcohol extracts of Ganoderma lucidum can reduce the HeLa cervical cancer cells and non-small cell lung cancer cell H441GLthe growth capacity, and to cell cycle arrest, and can inhibit tumor formation in vivo of the

other, non-invasive in vivo molecular imaging imaging can accurately and quickly analyze wine extracts in vivo tumor effect of Ganoderma lucidum for.

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