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FABAD J PHARM

SCI

OURNAL of ACEUTICAL

ENCES

Volume: 36 • Issue: 1 • March 2011

An Official Journal of The Society of

ISSN 1300-4182 www.fabad.org.tr

Pharmaceutical Sciences of Ankara (FABAD)

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The Society of Pharmaceutical Sciences of Ankara (FABAD) FABAD Journal of Pharmaceutical Sciences

Volume: 36 Issue: 1 March 2011

Publisher

Bensu Karahalil (Gazi University, Ankara, Turkey) Editor-in-Chief

Didem Deliorman Orhan (Gazi University, Ankara, Turkey) Associate Editors

Sultan BAYTAŞ (Gazi University, Ankara, Turkey) Ahmet Oğuz ADA (Ankara University, Ankara, Turkey)

Aysel BERKKAN (Gazi University, Ankara, Turkey) İ. İrem TATLI (Hacettepe University, Ankara Turkey)

Editorial Board

Nurettin ABACIOĞLU (Gazi University, Ankara, Turkey) Zeliha AKDEMİR (Hacettepe University, Ankara, Turkey) Asuman BOZKIR (Ankara University, Ankara, Turkey)

Ünsal ÇALIŞ (Hacettepe University, Ankara, Turkey) Erdal DİNÇ (Ankara University, Ankara, Turkey) Benay Can EKE (Ankara University, Ankara, Turkey) Fatma GÜMÜŞ (Gazi University, Ankara, Turkey) İlhan GÜRBÜZ (Gazi University, Ankara, Turkey) Süeda HEKİMOĞLU (Hacettepe University, Ankara, Turkey)

Blanca LAFFON (University of A Coruña, A Coruna, Spain) Levent ÖNER (Hacettepe University, Ankara, Turkey) A. Yekta ÖZER (Hacettepe University, Ankara, Turkey) Sibel ÖZKAN (Ankara University, Ankara, Turkey)

Yalçın ÖZKAN (Gulhane Military Medical Academy, Ankara, Turkey) Tanju ÖZÇELİKAY (Ankara University, Ankara, Turkey)

Nurten ÖZDEMİR (Ankara University, Ankara, Turkey) Rita De PASQUALE (University of Messina, Messina, Italy) Nadja Souza PINTO (University of Sao Paulo, Sao Paula, Brazil)

Selma SARAÇ (Hacettepe University, Ankara, Turkey) Sevgi ŞAR (Ankara University, Ankara, Turkey) Uğur TAMER (Gazi University, Ankara, Turkey) Maria Fernanda TAVIANO (University of Messina, Messina, Italy)

João Paulo TEIXEIRA (National Institute of Health, Porto, Portekiz) Meral TUNÇBİLEK (Ankara University, Ankara, Turkey)

Nilüfer TURAN (Gazi University, Ankara, Turkey)

Eva Maria Munoz VALENTINE (Univarsidade de Santiago de Compostela, Spain) Beata WALCZAK (University of Silesia, Poland)

Sulhiye YILDIZ (Ankara University, Ankara, Turkey)

Feyza SALTAN (Language Editor, Middle East Technical University, Ankara, Turkey)

Serhat Ali Arıkan (Language Editor, Ankara, Turkey)

The FABAD Journal of Pharmaceutical Sciences is published quarterly by the Society of Pharmaceutical Sciences of Ankara (FABAD)

All expressions of opinion and statements of supposed facts appearing in articles and / or advertisiments carried in this journal are published on the responsibility of the author and / or advertiser, and are not to be regarded those of the Society of Pharmaceutical Sciences of Ankara. The manuscript submitted to the Journal has the requirement of not being published previously and has not been submitted elsewhere. Manuscript should bu prepared in accordance with the requirements specified as in the back cover. The submission of the manuscript to the Journal is not a condition for acceptance; articles are accepted or rejected on merit alone. The Journal is distributed to the members only. Non- members can obtain the journal by a donation to FABAD. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems without written permission from FABAD Journal of Pharmaceutical Sciences.

The FABAD Journal of Pharmaceutical Sciences is indexed in Chemical Abstracts, Analytical Abstracts, International Pharmaceutical Abstracts, Excerpta Medica (EMBASE),

ISI Master Journal List, Scopus and Proquest

All manuscripts and editorial correspondences should be sent via e-mail to Didem Deliorman Orhan (Editor-in-Chief): fabadankara@gmail.com

The payment of donation has to be sent to the bank Account Number given below:

Türkiye İş Bankası, Gazi Mahallesi Şubesi, Ankara, Account number: 4286 304400 201434

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CONTENTS

Research Articles

1 Extended Release of Metoprolol Succinate from HPMC Reinforced Alginate Microparticle Rabinarayan PARHI, Padilam SURESH

11 Antimicrobial Activity of Some Verbascum Species Growing in Turkey

Çiğdem KAHRAMAN, Melike EKIZOĞLU, Didem KART, Zeliha Ş. AKDEMIR, I. Irem TATLI

17 Analysis of the Codon 72 Polymorphism of p53 Gene in Patients with Multinodular Goitre: A Risk Factor of Thyroid Cancer

Banu BAYRAM, Reşit SÖNMEZ, Sedat BOZARI, Harun ÖNLÜ, Fezan Mutlu ŞAHIN

25 Studies on the Conformity of Hibiscus sabdariffa L. Samples from Turkish Market to European Pharmacopeia

Fidan PESEN ÖZDOĞAN, Nilüfer ORHAN, Fatma ERGUN

33 Assessment of Hepatoprotective Activity of Achillea biebersteinii Ethanol Extract on Carbon tetrachloride-induced Liver Damage in Rats

Sanem HOŞBAŞ, Ali HARTEVIOĞLU, Mert PEKCAN, Didem DELIORMAN ORHAN Scientific Reviews

41 Reactive Oxygen Species (ROS) Generation in Sepsis- Review

Çetin KAYMAK, Hulya BASAR, Semra SARDAŞ

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