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The availability and effects on lipid metabolism of large dose β-carotene in rats fed different fat diets.

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高劑量β-胡蘿蔔素在攝取不同油脂大白鼠體內之利用率及對脂質

代謝的影響

The availability and effects on lipid metabolism of large dose β-carotene in rats fed different fat diets.

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中文摘要

本研究的目的是探討高劑量 β-胡蘿蔔素在攝取不同油脂大白鼠體內之利率,進 而研究 β-胡蘿蔔素在脂質代謝上所扮演的角色。將 80 隻 Wistar 品系雄性大白 鼠(重約 250 公克) ,隨機分成八組,以 β-胡蘿蔔素 (0.2 % ,給予或不給予)、

脂質種類 ( 黃豆油或豬油 )及脂質濃度(5 %或 15 %) 作 2×2×2 factorial 的設

計,於第3 週及第 6 週分別宰殺大白鼠,取血液及肝臟,測定血清與肝臟中三酸

甘油酯及總膽固醇含量,血清中並分析低密度脂蛋白膽固醇及高密度脂蛋白膽固 醇含量,同時利用 HPLC 分析血清及肝臟中β-胡蘿蔔素、維生素 A 含量。結 果顯示:食物攝取量無顯著差異;不論是否給予 β-胡蘿蔔素,高黃豆油組有顯 著較高的最終體重及餵食效率( P <0.01)。脂質分析方面,黃豆油/給予β-胡蘿 蔔素組之血清三酸甘油酯高於黃豆油/不給予β-胡蘿蔔素組,豬油組有相反的 結果( P=0.0007);第 3 週之肝臟三酸甘油酯,高黃豆油組顯著高於其它(P<0.05),

而第 6 週發現給予 β-胡蘿蔔素會降低肝臟三酸甘油酯 (P=0.0051) ;血清中總 膽固醇、高密度脂蛋白膽固醇及低密度脂蛋白膽固醇,於第 3 週無顯著差異,

6 週則是高油組高於低油組(P<0.05),且血清β-胡蘿蔔素濃度與高密度脂蛋白 膽固醇/低密度脂蛋白膽固醇比率呈負相關 (r=-0.35,P=0.0374)。第 3 週之肝 臟膽固醇在高油時,黃豆油組高於豬油組,低油時則相反 (P=0.0001),第 6 週時,

高黃豆油組顯著高於其它組(P <0.005)。血清及肝臟中 β-胡蘿蔔素有相同的趨 勢,第 3 週時,高油組顯著高於低油組( 血清,P=0.0028;肝臟,P=0.0001),

且高豬油組高於高黃豆油組(p<0.05)。β-胡蘿蔔素的給予對於血清維生素 A 在

3 週時無影響,第 6 週時則會降低;肝臟維生素 A 則會因β-胡蘿蔔素的給予

而上升。

英文摘要

The purpose of this study was to investigate the availability and the effects on lipid metabolism of large dose β-carotene (BC) in rats fed different fat diets. Male adult Wistar rats(N=88 ) were randomly divided into eight groups in a 2×2×2factorial design for three or six weeks. These diets varied in BC content (0.2 %, with or without), lipid type (soybean oil or lard) and lipid level (5 % or 15 %). Analytical items included serum tri- glyceride(STG), serum total cholesterol(SC), high density lipo- protein cholesterol(HDL-C), low density lipoprotein cholesterol (LDL-C), liver

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triglyceride(LTG) and liver total cholesterol(LC). HPLC was used to analyze BC and vitamin A concentrations. The re- sults showed that 15 % soybean oil group had higher final body weight and feed efficiency (p<0.0100). The effects on lipid meta- bolism were as follows: soybean oil/with BC group had higher STG than soybean oil/without BC group,and the lard groups had reverse result (p=0.0007); 15%

soybean oil group had highest LTG amomg eight groups after three-week feeding, and it was lowest when given BC after six-week feeding (p=0.0051); 15% oil/fat groups had higher SC, HDL-C and LDL-C than 5% oil/fat groups after six- week feeding (p<0.05), in addition, serum BC had negative correl- ation (r=-0.35, p=0.0374) with HDL-C/LDL-C ratio; 15% soybean oil group had higher LC than 15% lard group after three-week feeding, 5% oil/fat groups had reverse result (p=0.0001), but 15%

soybean oil group had highest LC after six- week feeding (p< 0.005). Serum and liver BC showed similar results that 15% oil/ fat groups had higher BC than 5% oil/

fat groups (serum, p=0.0028 ; liver, p=0.0001), and 15% lard group had higher BC than 15%salad oil group (p<0.05). With BC groups had lower serum vitamin A than without BC groups after six-week feeding. Liver vitamin A increased with the presence of BC (p<0.05).

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