IInd INTERNATIONAL VETERINARY
XVIth NATIONAL VETERINARY SURGERY CONGRESS
SURGERY CONGRESS OF TURKEY
XVI. ULUSAL VETERİNER
CERRAHİ KONGRESİ
I n C onClusIon
, It was aimed to share cases of dogs with whitish- greyish opacities without symptoms of inflammation in terms of thesignificance of blood and endocrine analyses to emphasize the diagnosis.
CO R N EAL L I P I D OS I S R E LAT E D TO CUS H I N G ’ S D I S EAS E I N T W O D O G S
Near East University, Faculty of Veterinary Medicine, 1 Department of Surgery, 2 Department of Biochemistry 3 Department of Internal Medicine, Nicosia, TRNC
Correspondence: cagri.gultekin@neu.edu.tr
Lipid keratopathy or corneal lipidosis is accumulation of adipose (usually cholesterol crystals) as grey-blue cloudy opacities in the cornea. We usually come across corneal lipid deposits in dogs as; corneal dystrophy which is hereditary and observed in both eyes successively, corneal degeneration as a result of the cornea’s chronic irritation which is usually observed in one eye, and less frequently, as a result of a systemic disease usually observed in both eyes due to high blood cholesterol [1,2,3].
Sharing our cases was found to be significant in terms of our patients’ diagnosis of Cushing’s disease affiliated with corneal opacities.
Two dogs who were a 4 years old, female, crossbreed and a 2 years old male Golden Retriever were brought to the Near East University Animal Hospital with the complaint of whitish opacities in the bilateral cornea.
Obvious disease symptoms were not observed in the systematic examinations of both cases. Moreover, in the ophthalmological examination, no symptom like lachrymal discharge, blepharospasm, photophobia, conjunctival rubescence or inflammation (red
eye) was observed. However, in the corneal examination, differently sized crystallized opacities in bilateral cornea were detected in both cases (Fig. 1).
The significant blood biochemical and
endocrinological laboratory results were manifested at table 1.
Both cases were diagnosed with hyperlipidemia related to high levels of cholesterol or triglyceride.
The reason for hyperlipidemia and corneal lipidosis was found to be Cushing’s disease, as a result of the high cortisol levels and low-dose dexamethasone suppression test.
D IsCussIon
References
1. Cooley PL, Dice PF. Corneal dystrophy in the dog and cat. Vet Clin North Am Small Anim Pract. 1990,20(3):681-92.
2. Degeneration of the Cornea in Dogs. Date of Update: 03.09.2018, https://wagwalking.com/condition/degeneration-of-cornea).
3. Crispin S. Ocular lipid deposition and hyperlipoproteinaemia. Prog Retin Eye Res. 2003,22(4):563.
I ntroDuCtIon
C ase D esCrIptIon
It was reported that corneal lipidosis is caused by hyperlipidemia, hypothyroidism, Cushing’s disease, diabetes, pancreatitis, hereditary lipid metabolism problems and diets including high levels of fat consumption 3. Lower total T4 concentrations in both cases was evaluated as a frequent symptom in hypercorticism, and the treatment of the disease was started.
Signalments: 4-year-old, female,
crossbreed dog 2-year-old, male, Golden Retriever
Clinical Biochemistry Results Reference Intervals
Glucose (mg/dL) 93,16 98,15 65,00-118,00
Fructosamine (µmol/L) 277,55 296,32 170,00-338,00
Cholesterol, Total (mg/dL) 223,58 472,81 135,00-270,00
Lipase (U/L) 21,35 5,91 13,00-200,00
Triglycerides (mg/dL) 192,41 103,55 22,00-125,00
Endocrinology
Cortisol (nmol/L) 396,07 275,02 15,00-110,00
T4, Total (nmol/L) 8,87 8,20 11,00-58,00
TSH (ng/mL) 0,075 0,064 0,02-0,59
Table 1. Laboratory results of two cases.
Clinical biochemistry tests were performed by using automated analyser. Endocrinology tests were done by using species specific ELISA assay kits.
Fig 1. Corneal lipidosis (red arrows) in two dogs. A and B: Right eye, centrally located, at 8 o’clock position; C: Left eye, centrally located, at 5 o’clock
position; D: Left eye, covering 2/3 of the cornea at the 3-7 o’clock position.
A,B,C: 4-year-old, female, crossbreed dog; D: 2-year-old, male, Golden Retriever.
Özgencil FE 1, Gökçe P 1, Gültekin Ç 1, Yeşilovalı G 1, Sayıner S 2, Turgut K 3
Lab.
Results Clinical Exam.
A B
C D
