Histone Deacetylase Inhibitors: A Prospect in Drug Discovery

A study of potential adverse drug- drug interactions among prescribed drugs in medicine outpatient department of a tertiary care teaching hospital. Assessment

As a part of this study, Molinspiration software was used to determine their physicochemical parameters (log P, TPSA, nrotb, molecular weight, number of hydrogen

In the analysis method, Hansch expressed that the observed biological effects of the compounds in a homologous series are a function of the physicochemical properties of

The various other approaches for lead optimization are Structure-Based Drug Design (SBDD), Quantitative Structure-Activity Relationship (QSAR) and Computer-Assisted Drug

• Since metabolism facilitates drug excretion, it is also important in designing compounds with modified duration of action. • Knowledge of metabolism can also help

In homology modeling, the amino acid sequence of a specific protein (target) is known, and the 3-D structures of proteins related to the target (templates) are known.

The quantitative structure-effect relationships (QSAR) of the compounds are explained by applying the Hansch analysis method using the obtained activity results... When the equality

Figure 7: Histogram of correspondence scores calculated for unknown condition pairs covered in the Hillenmeyer dataset, calculated using only negative genetic interactions,