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Roles of senescence escape and epigenetic modifications in liver cancer

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Figure  1.1:  Steps  of  the  hepatocellular  carcinogenesis:  A  normal  healthy  liver  can  transform into non-alcohol induced liver disease (NAFLD) or fibrosis
Figure  1.2:  Major  molecular  units  and  mechanisms  of  the  liver  fibrosis:  a)  Fibrogenic  activation  mechanism  of  myofibroblasts
Figure  1.3:  Multi-step  progressive  treat  and  molecular  mechanisms  of  hepatocellular carcinogenesis:  a) Different factors, such as viral infection and chronic alcohol  consumption induce injury in hepatocytes
Figure  1.4:  Different  senescence  response  mechanisms:  a)  Replicative  senescence,  mainly  driven  by  shortening  of  telomere  ,  activates  p16 INK4A   expression  and  activates  DNA  damage  pathways causing in p53 induction
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