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Clinical Interventions in Aging 2015:10 1069–1070
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http://dx.doi.org/10.2147/CIA.S88694
effect of proton pump inhibitor use on Helicobacter
pylori positivity and atrial fibrillation
Kadri Atay
1Omer Kaya
21Istanbul University, Cerrahpasa
School of Medicine, Division of Gastroenterology, 2Medipol
University, Department of Internal Medicine, Istanbul, turkey
Dear editor
We read with interest the report by Wang et al regarding the association between
Helicobacter pylori infection and atrial fibrillation.
1One of our concerns about this
well designed study is the lack of reporting of proton pump inhibitor (PPI) use in the
patients and controls. It is well known that use of PPIs influences the results of some
tests for H. pylori, including the urea breath test, which the authors used in their study.
Notably, the frequency of H. pylori antibody positivity was similar between all three
groups while H. pylori infection seems to be significantly more common in subjects
with long-standing atrial fibrillation. More frequent use of PPIs may potentially explain
the lower frequency of H. pylori positivity in the control group and short-term atrial
fibrillation group. Further, there are some recent reports indicating a protective effect
of PPIs on the risk of atrial fibrillation, especially in people with gastroesophageal
reflux disease.
2In conclusion, use of PPIs may have influenced some of the test results
in this study, including the risk of atrial fibrillation.
Disclosure
The authors have no conflicts of interest to disclose in relation to this
comm-unication.
References
1. Wang DZ, Chen W, Yang S, et al. Helicobacter pylori infection in Chinese patients with atrial fibrilla-tion. Clin Interv Aging. 2015;10:813–819.
2. Roman C, Bruley des Varannes S, Muresan L, Picos A, Dumitrascu DL. Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive review. World J Gastroenterol. 2014;20: 9592–9599.
Correspondence: Omer Kaya Istanbul Medipol University, esenler Hospital, Department of Internal Medicine, esenler, Istanbul, P.B. 34230, turkey
tel +90 53 1793 0386 email amerkaya@yahoo.com
Journal name: Clinical Interventions in Aging Article Designation: Letter
Year: 2015 Volume: 10
Running head verso: Atay and Kaya
Running head recto: Effect of PPI on H. pylori positivity and AF DOI: http://dx.doi.org/10.2147/CIA.S88694
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Atay and KayaAuthors’ reply
De-Zhao Wang
1Wei Chen
1Song Yang
2Jun Wang
3Qun Li
1Qiang Fu
2Shi-Jing Li
3Bu-Xing Chen
11Department of Cardiology, Beijing tiantan Hospital, Capital
Medical University, 2Department of Ultrasonography, Beijing
tiantan Hospital, Capital Medical University, 3Department of
Cardiology, Beijing Mentougou District Hospital, Beijing, People’s republic of China
Correspondence: De-Zhao Wang
Department of Cardiology, Beijing tiantan Hospital, Capital Medical University, No 6, tiantan Xili, Dongcheng District, Beijing 100050, People’s republic of China
tel +86 10 6709 6577 email dezhao.w@126.com
Dear editor
We are very glad to respond to the enquiry from Kadri Atay
and Omer Kaya about use of PPIs in our subject. This study
was a retrospective, cross-sectional analysis from a single
center, and patients with gastrointestinal disease and those
on PPI therapy before recruitment were excluded from the
study.
Disclosure
The authors report no conflicts of interest in this
comm-unication.
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