Results : The mean age of the PsA probands at assessment was 48.1 yrs (±14.6) (age of onset of PsC 26.4 (±12.1) and PsA 34.4 (±10.9) yrs). The mean age of PsC siblings at assessment was 53.1 yrs (±14.3) (age onset of PsC at 27.5 (±15.7). The PsA siblings at assessment was 55.2 yrs (±13.4), with age of onset of PsC at 29.4 (±14.9) and PsA 36.1 (±12.9) yrs. Finally, the mean age of assessment of unaffected sibling was 50.2 yrs (±13.2). A differential concordance rate was noted for three genes with PsC, 4 genes with PsA, six genes for PsC or PsA, compared to the unaffected sibling (Table). In addition, when the concordance of PsA siblings were compared to PsC siblings, LCE3A was more likely (OR 2.6, p=0.015) in PsA and HLA- B*3906 was less likely (OR 0.43, p=0.038) to be shared in PsA .
Conclusion : There is greater concordance of known susceptibility genes among PsA siblings and PsC siblings of PsA probands. The genotype of the PsA probands along with the siblings is helpful in determining siblings at risk and should be considered as a potential biomarker for risk prediction.
Disclosure : W. Badaiki , None; Q. Li , None; T. Burry , None; F. Landells , None; R. Gehue , None; C. Penney , None; D. Codner , None; A. Dohey , None; K. Smith , None; F. Abji , None; D. Gladman , AbbVie, 2, 5, Amgen, 2, 5, BMS, 5, Celgene, 2, 5, Eli Lilly, 2, 5, Galapagos, 5, Galapagos NV, 5, Gilead, 5, GSI, 5, Janssen, 5, Janssen Research & Devel-opment, LLC, 2, Novartis, 2, 5, P zer, 2, 5, UCB, 2, 5; D. O ’ Rielly , None; V. Chandran , None; P. Rahman , Amgen, 5, Abbott, 5, Janssen, 2, 5, 8, Novartis, 5, 8, Eli Lilly, 5, 8, P zer, 5, 8.
Abstract Number: 2500
Current Smoking Status Increases the Risk of Axial Psoriatic Arthritis:
An Explanation to Smoking Paradox
Dilek Solmaz , 1 Umut Kalyoncu , 2 Ilaria Tinazzi , 3 Sibel Bakirci , 4 Ozun Bayindir , 5 Atalay Dogru , 6 Ediz Dalk ç
ı ıl , 7 Gezmiş Kimyon , 8 Cem Ozisler , 9 Gozde Cetin , 10 Levent Kilic , 11 Ahmet Omma , 12 Meryem Can , 13
Sema Yılmaz , 14
Abdulsamet Erden , 15 and Sibel Zehra Aydin 16 , 1 Izmir Katip Celebi University, Faculty of Medicine, Department of
Internal Medicine, Division of Rheumatology, zmir, Turkey,İ 2 Hacettepe University Department of Rheumatology,
Ankara, Turkey, 3 Sacro Cuore Don Calabria Hospital, Unit of Rheumatology, Verona, Italy, 4 Antalya Education and
Research Hospital, Antalya, Turkey, 5 Ege University, Department of Internal Medicine, Division of Rheumatology,
Izmir, Turkey, 6 Suleyman Demirel University, Department of Internal Medicine, Division of Rheumatology,
Isparta, Turkey, 7 Uluda University, Bursa, Turkey,ğ 8 Mustafa Kemal University, Hatay, Turkey, 9 Diskapi Yildirim
Beyazit Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, 10
Kahramanmaras Sutcu Imam University, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, 11 Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of
Rheumatology, Ankara, Turkey, 12
Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, 13 Marmara University, Division of Rheumatology, Istanbul,
Turkey, Istanbul, Turkey, 14
Division of Rheumatology, Selcuk University School of Medicine, Konya, Turkey, Konya, Turkey, 15 Hacettepe University, Ankara, Turkey, 16 University of Ottawa Faculty of Medicine, Rheumatology,Ottawa
Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada
SESSION INFORMATION
Session Date: Tuesday, November 12, 2019
Session Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster III: Psoriatic Arthritis, Clinical Features
Session Type: Poster Session (Tuesday)
Session Time: 9:00AM–11:00AM
Background/Purpose : Smoking has been shown to be associated with an increased risk of psoriatic arthritis (PsA) in the general population, but there are controversies among patients with psoriasis. We hypothesize that smoking is a risk factor for axial PsA speci cally, similar to axial spondyloarthritis, more than the other PsA phenotypes.
Pr nted by [W ley Onl ne L brary - 078.190.043.140 - /do /epdf/10.1002/art.41 108] at [1 1/06/2021].
Methods : PsArt-ID (Psoriatic Arthritis- International Database) ] is a multicenter, international database, investigating the disease characteristics in real life. From that registry, 1535 PsA patients with smoking data were included for this analysis. Smoking status was categorized as never, current smoker or ex- smoker. Axial PsA was based on the clinicians’ judgement, requiring clinical features but not mandating any imaging. In addition grading of sacroiliitis was done by a central reader, whenever available. The effect of smoking, as well as other potential predictor factors on axial PsA and radiographic sacroiliitis, was assessed using a logistic regression analysis.
Results : Axial PsA was more common across current smokers compared to ex and non- smokers (38.9% vs 27.2% vs 26.8%, respectively; p< 0.001). Multivariate analysis to predict axial PsA showed that younger age [Odds ratio (OR)=0.98, 95% Con dence Interval (CI)= 0.97- 0.99, p=0.014], male gender (OR=1.49, 95% CI=1.17- 1.89, p=0.001), current smoking status (OR=1.42, 95% CI=1.07- 1.88, p=0.014) and presence of nail disease (OR=1.43, 95% CI=1.14- 1.80, p=0.002) were signi cant predictors for axPsA whereas polyarticular (OR=0.71, 95% CI=0.56- 0.89, p=0.003) and distal joint involvement (OR=0.56, 95% CI=0.40- 0.80 p=0.001) were protective (Table 1). Current smok-ing status was also found a signi cant predictor for radiographic sacroiliitis (OR=13.6, 95% CI= 2.87- 64.6, p=0.001) (Table 2).
Conclusion : Current smoking is a signi cant risk factor for both axial PsA and radiographic sacroiliitis in patients with PsA, and not the peripheral phenotypes.
Table 1. Multivariate analysis on factors associated with axial psoriatic arthritis
Pr nted by [W ley Onl ne L brary - 078.190.043.140 - /do /epdf/10.1002/art.41 108] at [1 1/06/2021].
Disclosure : D. Solmaz , None; U. Kalyoncu , UCB, 5; I. Tinazzi , None; S. Bakirci , None; O. Bayindir , None; A. Dog-ru , None; E. Dalkılıç , None; G. Kimyon , None; C. Ozisler , None; G. Cetin , None; L. Kilic , None; A. Omma , None; M. Can , None; S. Yılmaz , None; A. Erden , None; S. Aydin , None.
Table 2. Multivariate analysis on factors associated with radiographic sacroiliitis
Pr nted by [W ley Onl ne L brary - 078.190.043.140 - /do /epdf/10.1002/art.41 108] at [1 1/06/2021].
