• Sonuç bulunamadı

Does MESNA application make sense in chronic otitis media surgery?

N/A
N/A
Protected

Academic year: 2021

Share "Does MESNA application make sense in chronic otitis media surgery?"

Copied!
2
0
0

Yükleniyor.... (view fulltext now)

Tam metin

(1)

Letters to the Editor

Is MESNA an effective drug preventing recurrence of cholesteatoma after surgical treatment?

To the Editor:

We have read with pleasure the article by Kalcioglu MT. et al.[1]which presents very important clinical observations. We would like to make some comments on this problem, basing on our experience and the literature review. MESNA (sodium 2-mercapto-ethane sulphonate) is a synthetic sulfur com-pound that produces mucolysis by disrupting disulfide bonds of the mucus polypeptide chain. MESNA can be used during ear surgeries (cholesteatoma or atelectasis), to make the dissection of keratinocyte layers[2,3]. But a question remains over the possible mechanism of action of MESNA in chronic otitis media. Therefore, we would like to share our opinion in this subject. Cholesteatoma is composed of matrix (stratified squamous keratinizing epithelium with keratinocyte), layers of exfoliated epithelium with keratin, perimatrix (connective tissue) and, in most of the cases, bacterial biofilm consisting of colonies of Pseudomonas aeruginosa, Proteus mirabilis or Staph-ylococcus aureus[3]. In chronic otitis with atelectasis, one of the issues is to remove the keratinocytes released from the retraction pocket. MESNA contributes to breaking of the disulfide bonds in exfoliated keratinocytes, and therefore facilitating their removal. In open-type cholesteatoma (com-mon in children and in cholesteatoma recurrence) with presence of bacterial biofilm MESNA enables even easier and more efficient control of the exfoliated epithelium, especially in the environment with low pH[3]. In our department we administer MESNA into ears during the postoperative period. Its effectiveness will be assessed after its use in over a hundred patients [3]. In the light of our experience, we advocate the use of MESNA mainly in atelectatic ears, since, theoretically, it prevents implantation of keratinocytes in the postoperative tympanic cavity and recurrence of cholestea-toma[2–4]. Taken together, Kalcioglu MT. et al.[1]presented an interesting information on treatment of cholesteatoma, but their results need to be interpreted with caution. In our opinion MESNA can be an effective drug preventing recur-rence of cholesteatoma.

R E F E R E N C E S

[1] Kalcioglu MT, Cicek MT, Bayindir T, et al. Effectiveness of MESNA on the success of cholesteatoma surgery. Am J Otolaryngol Head and Neck Med and Surg 2014;35(3):357–61.

[2] Yilmaz M, Goksu N, Bayramoglu I, et al. Practical use of MESNA in atelectatic ears and adhesive otitis media. ORL J Otorhino-laryngol Relat Spec 2006;68:195–8.

[3] Kuczkowski J, Kobierska-Gulida G, Iżycka-Świeszewska E, et al. Molecular control of bone resorption in chronic otitis media with cholesteatoma. Otolaryngol Pol 2010;64:219–24.

[4] Van Spaendonck MP, Timmermans JP, Claes J, et al. Single ototopical application of MESNA has no ototoxic effects on guinea pig cochlear hair cells: a morphological study. Acta Otolaryngol 1999;119:685–9.

Jerzy Kuczkowski, MD, PhD⁎ Łukasz Plichta, MD Dept. Otolaryngology Medical University of Gdańsk; 80-211 Gdańsk Dębinki 7, Poland

Corresponding author. Email address:[email protected]

Joanna Cieszyńska, MD Dept. Otolaryngology Municipal Hospital St Vincent a Paulo Gdynia

http://dx.doi.org/10.1016/j.amjoto.2014.05.010

A M E R I C A N J O U R N A L O F O T O L A R Y N G O L O G Y – H E A D A N D N E C K M E D I C I N E A N D S U R G E R Y 3 5 ( 2 0 1 4 ) 6 8 7 – 6 8 8

Does MESNA application make sense in chronic otitis media surgery?

To the Editor:

We read the comments by Kuczkowski et al. regarding our manuscript published in the journal[1]. We would like to thank to the authors for their comments which in general support what we have observed in the use of MESNA. As the authors mentioned MESNA (sodium 2-mercapto-ethane sulphonate) is a synthetic sulfur compound that produces mucolysis by disrupting disulfide bonds. This way it facilitates the dissection of squamous epithelium in cases of retraction and adhesion. Moreover the likelihood of leaving some remnants of squamous epithelium may decrease, which is critical in terms of prevention of cholesteatoma recurrence.

As the authors have already quoted one of the articles published before[2], there is a clinical observation showing the practical use of MESNA in the middle ear surgeries. However, confirmation of these clinical observations is important, because MESNA also has hydraulic effect when injected, which may also help elevation of the retraction. This creates the critical question 0196-0709/© 2014 Elsevier Inc. All rights reserved.

A v a i l a b l e o n l i n e a tw w w . s c i e n c e d i r e c t . c o m

ScienceDirect

(2)

688

A M E R I C A N J O U R N A L O F O T O L A R Y N G O L O G Y – H E A D A N D N E C K M E D I C I N E A N D S U R G E R Y 3 5 ( 2 0 1 4 ) 6 8 7 – 6 8 8 as to whether MESNA helps dissection of the epithelium through

its chemical or hydraulic effect. Confirmation of this needs histopathological studies as well as case control studies compar-ing MESNA versus saline.

In conclusion, from a practical point of view and based on our observation MESNA seems to help dissection of the squamous epithelium. It is encouraging to know that Kuczkowski et al. share the same idea with us and have a similar observation. We look forward to seeing their study results in the near future.

R E F E R E N C E S

[1] Kalcioglu MT, Cicek MT, Bayindir T, et al. Effectiveness of MESNA on the success of cholesteatoma surgery. Am J Otolaryngol 2014;35(3):357–61.

[2] Yilmaz M, Goksu N, Bayramoglu I, et al. Practical use of MESNA in atelectatic ears and adhesive otitis media. ORL J Otorhino-laryngol Relat Spec 2006;68(4):195–8.

M. Tayyar Kalcioglu, MD* Department of Otorhinolaryngology Istanbul Medeniyet University Yildirim A. Bayazit, MD Department of Otorhinolaryngology Medipol University, Istanbul, Turkey *Corresponding author at: M. Tayyar Kalcioglu Istanbul Medeniyet University, School of Medicine Department of Otorhinolaryngology, Istanbul, Turkey E-mail addresses:[email protected]

Referanslar

Benzer Belgeler

Comparison of theoretical results with solid works data (Compressive stress) Table 5 Gear Materials Design Compressive Stress limit Calculated value Solid works von mises

The most commonly determined causes of the disease etiology are skull and temporal bone traumas; the other less commonly detected causes are viral labirynthitis,

Prevalence and risk factors for persistent otitis media with effusion in primary school children in Istanbul, Turkey. Caylan R, Bektas D, Atalay C,

Results: The sensitivity, specificity, and positive and negative predictive values of preoperative high-resolution CT (HRCT) were 52%, 88%, 73%, and 75%, respectively, for

(28) showed that improved glycemic control in patients with type 1 DM is associated with regression of septal thickness and left ventricular mass without significant effect

.ÕUÕOJDQOÕ÷Õ |OoPHN LoLQ oHúLWOL J|VWHUJHOHU NXOODQÕOPDNWDGÕU %X J|VWHUJHOHUGHQ ELU WD QHVL NÕUÕOJDQOÕN HQGHNVOHULGLU %DQNDFÕOÕN NÕUÕOJDQOÕN

Benfotiamin’in tedavi olarak verildiği Doksorubisin + benfotiamin grubunda ise Doksorubisin grubuna göre Kaspaz-3 immünreaktivitesinde belirgin azalmanın, kontrol

Deney grubunda öntest ve sontest verileri üzerlerinde yapılan karşılaştırma sonuçlarına göre; çocuklarda cinsiyet ayrımı yapılmadan koşma, top atma, top