酒精攝取對於大白鼠腦部及血液脂肪酸比例變化的影響 楊惠婷1、徐詩雯2、張愛漂2、黃士懿2 1臺北醫學大學藥學系博士班、2臺北醫學大學保健營養學系 本研究旨在探討飲水中添加酒精對於實驗動物（Sprague Dawley）體內脂肪 酸代謝是否造成影響。實驗共分為雌、雄鼠二組（n=25），於實驗初期先犧牲一 批實驗動物(每組 5 隻)作為基準組，進入實驗期後於飲水中加入 30%酒精，每日 紀錄飲水量，於每週犧牲一批動物(每組各五隻) ，連續給予一個月後全數犧牲， 收集血液及組織檢體進行紅血球及腦部磷脂質脂肪酸分析，並依不同時間點進行 比較。結果發現，隨著酒精的攝取，血液中 n-3 族脂肪酸比例有顯著下降的情形 (p<0.05)，其中二十二碳六烯酸(DHA)的比例也明顯下降，至第四週時仍無回復 之情形。而腦部的 n-3 族脂肪酸於第 3 週後也有下降的趨勢(p<0.05)，與第 0 週 相比較，酒精的攝取對於腦部 n-6 族也有顯著的影響。此實驗於雄鼠與雌鼠間均 呈現出相似的結果。因此，本研究證實連續一個月酒精的攝取不論是雄性或是雌 性大白鼠的腦部脂肪酸組成，尤其是 n-3 族脂肪酸代謝造成影響，此結果亦反映 在週邊紅血球磷脂質脂肪酸組成上，腦部脂肪酸代謝與週邊紅血球磷脂質脂肪酸 於高量酒精攝取下呈現高度的正相關性(r = 0.82, p<0.05)。 關鍵詞：酒精、紅血球磷脂質、n-3 族脂肪酸、二十二碳六烯酸
酒精攝取對於大白鼠腦部及血液脂肪酸比例變化的影響
1
0
0
Tam metin
Benzer Belgeler
Total antioxidative status (TAS), activities of antioxidative enzymes, lipid peroxidation (TBARS), total cholesterol (TC), triglyceride (TG), glutamic oxalic transaminase
Total antio xidative status (TAS), activities of antioxidative enzymes, lipid peroxidation (TBARS), total c holesterol (TC), triglyceride (TG), glutamic oxalic transaminase
The effects of carotenoids on the antioxidative status and lipid peroxidation in primary rats hepatocytes.. The studies have shown the important roles of
The animals in both experiments were normal male Sprague-Dawleys (SD) and randomly assigned into four groups, control (AIN-76), low dose chicken essence diet (AIN-76 plus 1.5
In male subjects, the 16:0 level of total plasma fatty acids had significantly increased, and the 18:2 and total n-6 polyunsaturated fatty acids levels as percentages of total
In male subjects, the 16:0 level of total plasma fatty acids had significantly increased, and the 18:2 and total n-6 polyunsaturated fatty acids levels as percentages of total
中文摘要 心血管相關疾病(cardiovascular disease, CVD)
Fifty-four male, 202g Wistar rats were randomly divided into six groups: casein group which accorded to AIN-76 diet formular without cholesterol; and other five groups with
