Scifinder 學習心得與使用成果報告
指導老師:吳建德老師
班級:
D 班
學號:
B303098167
壹. 正文
65. MDMA: Interactions with other psychoactive drugs
By: Mohamed, Wael M. Y.; Ben Hamida, Sami; Cassel, Jean-Christophe; Pereira de Vasconcelos, Anne; Jones, Byron C.
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is one of the most widely abused illegal drugs. Some users self-report euphoria and an increased perception and feeling of closeness to others. When taken in warm environments, MDMA users may develop acute complications with potential fatal consequences. In rodents, MDMA increases locomotor activity and, depending on ambient temp., may produce a dose-dependent, potentially lethal hyperthermia. Like most other recreational drugs, MDMA is frequently taken in combination with other substances including tobacco, EtOH, marijuana, amphetamines, cocaine and, caffeine. Although polydrug use is very common, the understanding of the effects of this multiple substance use, as well as the anal. of consequences of different drug-drug assocns., received rather little attention. The purpose of this review is to summarize our current knowledge about the changes on MDMA-related behavior, pharmacol., and neurotoxicity assocd. with co-consumption of other drugs of abuse and psychoactive agents.
貳
. 索引
Pharmacology
參. Concepts
Human
3,4-methylenedioxymethamphetamine increased locomotor activity and may develop lethal hyperthermia in rodent while its interaction with other drugs of abuse and psychoactive agents may cause neurotoxic effect in human
Neurotoxicity
3,4-methylenedioxymethamphetamine increased locomotor activity and may develop lethal hyperthermia in rodent while its interaction with other drugs of abuse and psychoactive agents may cause neurotoxicity in human
Behavior
3,4-methylenedioxymethamphetamine increased locomotor activity and may produce dose-dependent potentially lethal hyperthermia depending on ambient temp. in rodent
Substance abuse
3,4-methylenedioxymethamphetamine interaction with drug of abuse including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human
Combination chemotherapy
3,4-methylenedioxymethamphetamine interaction with psychoactive agents including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human
Fever and Hyperthermia
3,4-methylenedioxymethamphetamine may produce dose-dependent potentially lethal hyperthermia depending on ambient temp.
Behavior
locomotor; 3,4-methylenedioxymethamphetamine increased locomotor activity and depending on ambient temp. may produce dose-dependent potentially lethal hyperthermia in rodent
Cannabis sativa
marijuana; 3,4-methylenedioxymethamphetamine interaction with psychoactive agents including tobacco, ethanol, marijuana, amphetamine, cocaine and caffeine may develop acute complication with potential fatal consequences in human