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Hyperspectral stochastic optical reconstruction Raman microscopy for label-free super-resolution imaging using surface enhanced Raman spectroscopy

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Fig. 14.1 Description of the HYPERSTORRM Microscope. (a) A biological sample (such as a cell membrane, self-assembled supramolecular structures, extra or intracellular matrix  compo-nents) is placed on a high performance and high uniformity plasmonic subst
Fig. 14.2 Preliminary optical design for HYPERSTORRM imaging. (a) A Raman microscope is modified to incorporate a high sensitivity camera and high efficiency transmission grating to form a hyperspectral imaging system
Fig. 14.3 Engineering high-performance plasmonic substrates. (a) Basic Metal-Insulator-Metal (MIM) structure used for high uniformity SERS enhancement
Fig. 14.4 Stochastic reconstruction SERS imaging of self-assembled peptide nanostructures: (a) Reconstruction of a peptide layer imprinted onto the plasmonic substrate using an elastomeric mold
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