TROP2 expression in endometrioid type endometrial carcinoma and correlation with the prognostic factors

PS-02~13

TROP2 txpn.'SSion in (-ndomclriıoid l)'pt' endomdrial t:an.-inomıı and ccırrelation wilh thc pn,g.noııtic rıu:tonı

O. llhanC!l!i!İ. S.Y.

c

~

• Mug.la Silki Kocman University.. Faculty of Modicinc-. Dcp:trtment of

Paıhology. Tur\:cy

Background & Objt'<'tfres: E.ndomettioid ıype (EEC) endometrial car-cinoma is lhc mosı common malignancy of ıhe female gen.ita) tract in devclopod countrics. The incidcnce and the dcath ratcs have been incrcas-ing in the recent decadcs. iL is known tbaı the pfOb'llOSi'i of EEC ı;mıdy depcnds on the g_rade and ıhe

stage

and has ~'Ood prognosi.ı; when di.aı­ nosal in early S1ages. 1-lowcYa in some palİcnts the disease rccur in a short time aftct" ıhe ırcatmcnL Jn thcsc recum:nt di~scs lhc pmg.nosis worscn and thc survivals shortı:n. So it is importıınt ıo pn:dicı the patienıs

S84

The aim of this study is todetenninc. the oorrelaıion bc:twecn ıhe rcsults of cen~cal cytology and colposoopic biopsy ııpplied to HPV 16 or 18 pos· itfre women.

Mrthocb: Women who wen:: Sc.TCern:d by both hrHPV and cervical t.')'· tology bctwcen Januwy 2014 -Deoe-mbcr 2018 were evaluatod. Among

them. HPV 16 and 18 positivc 101 paticnl<ı who underwenl c.olposcopy wac includod in lhe study.

Rt.-suhıı: The cytology rcsults of 48 of IOI women werc NUJ,1 (ncgativc for intrucpithclial lcsiorıs or maliı;nancic:s). 3 of lhcm werc inadequate. Although oolposcopic biopsy rc.\-ults of 38 (79%) of ı.hem wcre in oorrc-lation ...,;th C)1ology, in 10 (21 %) oflhcm a cervicaJ pathology was

diag-n0<cd ( CiNi (n:S). CIN2 orCINJ (n: 4)and CiN can not begradcd due to inadccıuaıc biop.çy (n:I)

J

.

Cytology slideı. oflhese 10 ruscs wcre rc-c.valuaıod. lntctpn:1ation amr waii dctccıcd in 4 ofthc:m aud lhcy wac upgr.ı.ded to A.SC-US. ASCH or Sil catcgory. As a rcsult 6 (5.9%) patients ',\'Ould be misdiagnoscd if they would ha,·c enluatod wilh smı:ar

onJy. 50 of 101 womcn had p~t:ivc cytology rcsult<ı (ASC-US. LSIL. ASC-H or HSlL}. Colposc.-opic b-iopsy diag.nosis of 11 (22%) womcn wac discordant with cytokıgy and reportod as non•neoplastic. The cytol -ogy re.-,ı.ıhs of thcsc cases were ASC-US in (n:4). LSLL (n:3). ASC-H (n:2) and HSLL (n:2). Both the cytology and biopsy slides wcre rc-c,;aluatod and the n:sulL.:; wcre con fınnod. As a result 11 ( 1 O. 9 % ) pa1jents would be misdiagnoscd ifthey wookl have cvaluaıcd v..iıh colposcopic

biopsy only.

Conduııion: Cervic.al canccr scr.etning meth<>ds are onc of lhc fcw screening methods lhat arc lhoughı to n:ducc lhc incickmıe and mortuJity of inwsive canccr and havc proven cffcctive in lhis rcspcct. The.reforc. it is important ıo pcrfonn ıhis scrccning with thc mos.t appropriatc.- mcthod. A<.-cording to lhe resulı.s of our study. colposcopic biopsy aleme havc a

higher rate of mi~ing a ccrvical pathology whcn cmnpu.rcd to cytology alone. Thercfore in women with HPV 16 or l 8 posüi,'lıy. cyl'ology