The Effects of Pterostilbene and Resveratrol on the Biomechanic, Biochemical and Histological Parameters in Streptozotocin-İnduced Diabetic Rats Gastrocnemius Muscle

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The Effects of Pterostilbene and Resveratrol on The Biomechanic, Biochemical

and Histological Parameters in Streptozotocin-Induced Diabetic Rats

Gastrocnemius Muscle

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EDITORS:

SBE - Sociedad de Biofísica de España

http://biofisica.info/

July 2017

ISSN 2445-43111

life version at:

S1

Abstracts of the 16th SBE Congress P2 - Membrane Function Structure and Function

The Effects of Pterostilbene and Resveratrol on The Biomechanic,

Biochemical and Histological Parameters in Streptozotocin-Induced

Diabetic Rats Gastrocnemius Muscle

B. Tastekin,a _{A. Pelit,}a _{I. Günay,}a _{S. Polat,}b _{A. Tuli,}c _{L. Sencar,}b _{G. Coskun,}b

M.M. Alparslan,c _{Y.K. Daglioglu}d

a_{Çukurova University, Faculty of Medicine, Department of Biophysics, Adana, Turkey,}b_Çukurova

University, Faculty of Medicine, Department of Histology, Adana, Turkey,c_{Çukurova University,}

Faculty of Medicine, Department of Biochemistry, Adana, Turkey,d_{Çukurova University, Research}

and Practice Center of Experimental Medicine, Adana, Turkey

INTRODUCTION: Diabetes Mellitus (DM) is believed to have negative effects such as skeletal muscle atrophy, lower muscle mass, weakness and reduced physical capacity. A great number of studies have reported that antioxidant resveratrol and pterostilbene treatments could enhance the various metabolic disorders associated with diabetes. The aim of this study is to investigate the comparative effects of pterostilbene (PTS) (trans-3,5-dimethoxy-4I-hydroxystilbene) and resveratrol (RSV) (trans-3,5, 4I-trihydroxystilbene) applied at different doses in the treatment of streptozotocin (STZ)-induced diabetic myopathy. MATERIALS AND METHODS: Eighty rats of Wistar albino species were used. The animals were divided into eight groups (n = 10): control (non-diabetic); diabetic (DM); DM+10 mg/kg PTS; DM+20 mg/kg PTS; DM+40 mg/kg PTS; DM+10 mg/kg RSV; DM+20 mg/kg RSV and DM+(10+10) mg/kg PTS/RSV combination. At the end of the 5-week experimental period, the right gastrocnemius muscles of the rats were examined biomechan-ically, while the left ones were examined histologically. In addition, blood glucose, serum insulin and malondialdehyde levels were analyzed in blood samples taken from rats. FINDINGS AND RESULT: The skeletal muscle isometric contraction forces shown a decrease with diabetes were observed to have increased more with PTS antioxidant applications as compared to RSV applications. Blood glucose, serum insulin and malondialdehyde levels in diabetic rats were found to be closer to normal level with PTS applications. When the skeletal muscle electron microscopic images of diabetic rats treated with antioxidants were examined, Those in the mix treatment group were observed to showing better healing in Type-1 DM compared to the other diabetic and treatment groups. We suggest that PTS antioxidant treatments could be a better therapeutic nutraceutical alternative in skeletal muscle diseases coexisted with diabetes compared to RSV treatments.

Synergistic effect of membrane-active peptides SP-A and SP-BN on

multidrug-resistant Klebsiella pneumoniae

V. Fraile-Ágreda,a,b O. Cañadas-Benito,a,b C. Casals-Carroa,b

a_{Universidad Complutense de Madrid, Madrid, Spain,}b_{Centro de Investigaciones Biomédicas en Red}

de Enfermedades Respiratorias (CIBERES), Madrid, Spain

The emergence of multi-resistant strains of the respiratory pathogen Klebsiella pneumoniae under-lines the need to implement new non-antibiotic therapies, including the characterization of natural antibacterial proteins as a paradigm for endogenous defense pathways. We have previously shown that lung surfactant protein (A), acting synergistically with the lung anti-microbial peptide

SP-BN_{, enhances capsulated K. pneumoniae K2 clearance in vivo, in part by contributing to bacterial}

killing. However, the factors that govern SP-A/SP-BN _{anti-microbial activity are still unclear. The}

Author Index Abstracts of the 16th SBE Congress Pey, A.L., 52,90 Pinto, S.N., 74 Polat, S., 123 Ponce-España, E., 102 Pons, M., 85, 86, 113 Prado, A., 99 Prieto, M., 74 Pérez-España, E., 101 Pérez-Gil, J., 29,122 Pérez-Lara, A.,44 Pérez-Mejías, G., 101, 102 Pérez-Payá, E., 60 Pérez-Ruiz, V.D.M., 98 Pérez-Sánchez, D., 74 Pérez-Sánchez, M.D., 59 Pérez-Verdaguer, M., 132 Queralt-Martín, M., 36,133,134 Rafie, K., 114 Redondo-Morata, L.,149 Reina, O., 53 Rico, F., 149 Riedel, D., 127 Riezman, H., 45 Riezman, I., 45 Ringach, D., 25 Ritort, F., 23 Rivero-Rodríguez, F., 38,66,112,117,148 Robles, C., 109 Rodríguez, B., 90 Rodríguez, C.F., 110 Rodríguez-Arrondo, J.L., 77,128 Rodríguez-Frade, J.M.,118 Rodríguez-González, I., 125 Rodríguez-Larrea, D., 51,87,90,127 Rodríguez-Lumbreras, L.A.,109 Roig, S.R., 59 Rojas, A., 109, 115 Rojas, A.L., 100,114 Roldan, N., 122 Romano, M., 109 Romano-Moreno, M.,100 Romero-Tamayo, S., 39 Roncel, M., 140 Rosenbaum, J., 89 Roux, A., 78 Roux, A.L., 113 Rouzic, L., 91 Rubio, V.,37,67,105 Rubén-Barroso, R., 118 Rujas, E., 41, 77,99 Sachse, C., 70 Saita, M., 108 Salas, M., 86 Salgado, J., 43, 44 Salvatella, X., 53 Sanchez-Angulo, C., 75 Sancho, J., 49 Sancho, M., 60 Sancho-Sanz, J., 50 Santiago, C.A., 118 Santoro, J., 116 Santos, N., 73, 76 Santos-Ocaña, C., 97 Sastre, D., 59, 133 Schmidt, C., 44 Scott, J.K., 41 Sebastián, M., 96 Sencar, L., 123 Seoane, J., 31 Serrano, A., 96 Serrano, L., 128 Serrano-Albarrás, A.,59 Serrano-Novillo, C., 133 Silva, L.C., 74 Sivakumaran, A., 84 Skehel, J.M., 117 Soleimanpour, S., 78 Solís, D., 82 Sorzano, C.O., 118, 119 Sot, J., 121 Stephan-Otto, C., 53 Strzalka, K., 144 Suay-Corredera, C.,128 Svanström, A., 69 Sánchez, A., 73 Sánchez-Madrid, F., 118 Tabares, L., 78, 142–144 Tastekin, B.,123 Teixeira, J.M.C., 86 Tejero, R., 142 Thapaliya, A., 50 Timothy, E.,115 Tinao, B., 86 Todt, F., 60 156 Biofísica S1, 2017

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