Relationship between discordance of lipid parameters and mortality after acute coronary syndrome

(1)

Conclusions: The association between BMI and physical activity with the lipid profile indicates an influence of these factors and the need of an in-tegrated strategy to lipid management including lifestyle modifications. Posters 26 - 29 May, 2019

05. Cardiovascular disease: risk, prevention, and treament - 05.01 Cardiovascular disease and risk factors

EAS19-0723.

RELATIONSHIP BETWEEN DISCORDANCE OF LIPID PARAMETERS AND MORTALITY AFTER ACUTE CORONARY SYNDROME

O. Kurmus, M. eren, T. aslan. ufuk university, cardiology, balgat, ankara, Turkey

Background and Aims: Sizeable proportion of patients have discordant low density lipoprotein cholesterol (LDL-C) and non-high density lipo-protein cholesterol (NHDL-C). We assessed whether this discordance have impact on mortality in patients with acute coronary syndrome (ACS). Methods: We retrospectively evaluated the data of 198 consecutive pa-tients with ACS. Fasting serum lipid proﬁles were recorded, GRACE and TIMI scores were calculated. Mortality and cardiovascular events (heart failure, non-fatal myocardial infarction and angina) at sixth months were recorded. Percentile distributions of LDL-C and NHDL-C were calculated. Patients were divided into 3 groups according to percentiles : Discordant group : LDL-C<NHDL-C(n¼38), concordant group: LDL-C¼NHDL-C(n¼112) and discordant group LDL-C>NHDL-C(n¼48).

Results: TIMI risk score didn’t differ among discordant or concordant groups. Mean GRACE score was higher in group with LDL-C<NHDL-C than with LDL-C¼NHDL-C and LDL-C>NHDL-C (p¼0,029). There wasn’t signif-icant difference between LDL¼NHDL-C and LDL-C>NHDL-C regarding to GRACE score (p¼0.723). Percentage of cardiovascular events and mortality at sixth months were not different among groups (p¼0,473 and p¼0,176). Conclusions: There is no difference regarding mortality rates and car-diovascular events after ACS between LDL-C and NHDL-C concordant and discordant groups.

Posters 26 - 29 May, 2019

EAS19-0834.

STUDY OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

A. Ceasovschih1_{, V. Sorodoc}1_{, V. Aursulesei}2_{, D. Tesloianu}3_{, I.M. Jaba}4_{, C.} Dima Cozma2_{, B. Mihai}5_{, C. Statescu}2_{, C. Lionte}1_{, O. Sirbu}1_{, A.} Stoica1, L.G. Vata1, A. Coman1, C. Bologa1, R. Haliga1, G. Puha1, G. Dumitrescu1_{, M. Constantin}1_{, L. Simionov}3_{, L. Sorodoc}1_.1_{Grigore T. Popa}

University of Medicine and Pharmacy, Internal Medicine, Iasi, Romania;

2_{Grigore T. Popa University of Medicine and Pharmacy, Cardiology, Iasi,}

Romania;3_{Emergency Clinical Hospital "Sf^antul Spiridon", Cardiology, Iasi,}

Romania;4_{Grigore T. Popa University of Medicine and Pharmacy, Statistics,}

Iasi, Romania; 5_{Grigore T. Popa University of Medicine and Pharmacy,}

Diabetes, Iasi, Romania

Background and Aims: This study aimed to identify the cardiovascular risk factors proﬁle in patients with PAD compared to the non PAD patients in our region.

Methods: This prospective study included all the patients admitted in the 2ndDepartment of Internal Medicine and the Department of Cardiology of the Emergency Clinical Hospital "Sf^antul Spiridon" Iasi, enrolled consec-utively between August 2016 and April 2017. Ankle-brachial index (ABI) was performed to all the patients together with demographic and clinical data: age, gender, current smoking, presence of diabetes mellitus (DM), dyslipidemia and hypertension were monitored. Patients were divided into 2 groups: with PAD and without PAD.

Results: Our study included 3,430 patients, 46.8% male and 53.2% female, with an average age of 66.17 years. PAD was detected in 4.8% of cases. The cardiovascular risk factors elements were compared in PAD patients vs non PAD: age mean e 70.0 vs 65.3 years (p<0.072), men e 77.4% vs 45.3%,

current smokinge 87.8% vs 33.4% (p<0.0001), presence of DM e 36.6% vs 15.8% (p<0.0001), dyslipidemia e 100% vs 43,3% (p<0.0001) and hyper-tensione 90.9% vs 52.1% (p<0.0001).

Conclusions: Similar to literature data, the major risk factors for PAD are dyslipidemia, hypertension, cigarette smoking and DM. Establishing regional hierarchy of risk factors is useful for future better local prevention strategies.

EAS19-0857.

CARDIOVASCULAR RISK IN SYSTEMIC LUPUS ERYTHEMATOSUS M. Kechida1_{, W. Jomaa}2_{, R. Mesfar}1_{, S. Daada}1_{, R. Klii}1_{, S. Hammami}1_{, I.} Khochtali1_. 1_{Fattouma Bourguiba University Hospital, Internal Medicine}

and Endocrinology Department, Monastir, Tunisia; 2Fattouma Bourguiba University Hospital, Cardiology B Department, Monastir, Tunisia

Background and Aims: Patients with systemic lupus erythematosus (SLE) seem to have higher cardiovascular risks (CVR) as they combine traditional and non- traditional CVR factors. We aimed to determine the CVR in SLE patients and its correlation with disease activity and systemic manifestations

Methods: Medical records of 89 patients diagnosed with SLE according to the modiﬁed ACR criteria of 1997 were retrospectively analyzed. CVR was assessed using the Framingham Risk Score to estimate the 10 years CVR. It’s considered low if less than 10%; moderate if it’s between 10 a 20% and high if over 20%.

Results: The mean age was 35 years with a sex ratio M/F¼ 0.1. About 3.4% of the patients were smokers, 4.5% diabetes, 10.1% with high blood pres-sure and 3.4% dyslipidemic. The mean Body mass index was 25.9 kg/m2. Mean cholesterol levels were 4.38 mmol/l, Triglyceride 2.04, HDL 1.38 and LDL 1.74. Mean SLEDAI score was 9 and mean Framingham score was 2.58%. The CVR was considered low in 55.6% of the patients and moderate in 44.4%. Framingham score was inversely correlated with renal clearance (p¼0.037) and with neutrophile to lymphocyte ratio (p¼0.06) without reaching the signiﬁcant level. There was no correlation with disease ac-tivity, inﬂammatory parameters or systemic manifestations.

Conclusions: Despite the high disease activity in our patients and the high levels of inﬂammatory parameters, no one of our patients was presenting with high CVR according to Framingham score. Thus, Framingham score seems not suitable to estimate the CVR in inﬂammatory diseases especially SLE.

EAS19-0875.

PROFILING OF RISK OF SUBCLINICAL ATHEROSCLEROSIS BY GENETIC AND ENVIRONMENTAL FACTORS

I. Sobenin1,2_{, T. Kirichenko}1,2_{, Z. Khasanova}1_{, M. Iltchuk}2_{, V. Orekhova}1_{, V.} Sinyov1,2_{, A. Melnichenko}1_. 1_{National Medical Research Center of}

Cardiology, Institute of Experimental Cardiology- Laboratory of Medical Genetics, Moscow, Russia; 2_Institute _of _General _Pathology _and

Pathophysiology, Laboratory of Angiopathology, Moscow, Russia

Background and Aims: This study was performed to explore geographical, genetic and environmental factors associated with predisposition to ca-rotid atherosclerosis in high-risk individuals.

Methods: In Moscow population-derived cross-sectional study, 470 apparently healthy subjects with a high cardiovascular risk were recruited. To assess the susceptibility to the development of atherosclerosis, a high-resolution ultrasound scanning of common carotid arteries was used. The hypothesis on the possible interplay of genetic and environmental factors with conventional approach to cardiovascular risk assessment was tested. Genetic factors included the levels of heteroplasmy of mitochondrial genome for 10 mutations. Environmental factors were considered as the Abstracts / Atherosclerosis 287 (2019) e123ee288