Multiple Sclerosis Journal 2019; 432–492
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Multiple Sclerosis Journal 25(3)
dysfunction in visual space structure and attention was significantly(P<0.05).
Conclusion:
1. Patients with IDDCNS got CI in different ranks and ranges. 2. Patients with IDDCNS caught the significant CI shown as
dysfunction in visual space structure and attention. 3. Patients with IDDCNS carried APOE genotype asε3/3
more than other else subtypes.
4. The data showed the course of IDDCNS and the EDSS score maybe had insignificantly related to CI with IDDCNS.
P-26
The Correlation of Optical Cohorence Tomography Findings with Serum Cytokine Levels, TNF-α, Serum Neopterin Levels in Relapsing and Remitting Periods of MS
Hakan Ekmekci1, Fettah Eren2, Gözde Ongun1, Şansal Gedik3, Ali
Ünlü4, Şerefnur Öztürk1
1Selçuk University, School of Medicine, Deparment of Neurol-ogy, Konya – Turkey; 2Konya Education and Research Hospital, Department of Neurology, Konya – Turkey; 3Selçuk University, School of Medicine, Deparment of Ophtalmology, Konya – Tur-key; 4Selçuk University, School of Medicine, Deparment of Bio-chemistry, Konya – Turkey
Background: Optical Coherence Tomography (OCT) is an improved technique in the last 20 years that allows quantitative measurement of retinal nerve fiber layer (RNFL) thickness, which provides important information on approach to optic nerve dis-eases in neurology and ophtalmology area. Therefore, OCT is now being used in various neuro- ophthalmic situations.
On the other hand it is known that MS is also involved in a highly complexity of countless biomarkers that are elucitaded an autoimmune disease of the central nervous system. Serum and Cerebrospinal fluid Cytokines, TNF-α, neopterin (a marker of INF-β activity) may play important role in cell swelling, synaptic transmission and neural integration.
Objective: The main purpose of this study is to determine whether there is a correlation in between serum biomarker with RNFL findings in OCT amongs RR periods in MS.
Methods: 33 RR-MS patients and 30 Healthy volunteers who were followed at Neurology and Oftalmology Department of Selcuk University, were included at period of 2014-2018.
Serum levels of IL-6, IL10, TNF-α and Neopterin in acute exacerbation periods of MS patients were investigated. The data were compared with control group.
Results, Conclusions: Among all the groups examined (controls, Relapsing and Remitting period of MS), only a positive signifi-cant correlation was observed between the RNFL thickness and TNF-α level. This association is only present during the acute epi-sode. It was noteworthy that other bio-markers examined did not interact with MS's attacks. Serum TNF-α levels may have a role in RR-MS, which is the most valuable finding of this study. P-27
Withdrawn
P-28
Transorbital Ultrasonography in Acute Optic Neuritis: Can It be A Supportive Diagnostic Tool?
YJ Kwon1, SH Baek1, YH Kim1,2, BJ Kim 1*
1Department of Neurology, Korea University Medical Center, Seoul, Korea; 2Department of Neurology, Hallym University Medical Center, Seoul, Korea
Background: Because of the limitations of conventional tools for diagnosing optic neuritis (ON), transorbital ultrasonography (TOUS) has been introduced as a promising tool to evaluate optic nerve. However, there are scarce studies to demonstrate its utility.
Objective: To assess the practical diagnostic value of TOUS in patients with ON with analyzing multiple other diagnostic tools, such as visual evoked potential (VEP), magnetic resonance image (MRI), and optical coherence tomography (OCT).
Methods: A total of 17 patients with first-attack unilateral acute ON were enrolled. The clinical characteristics, visual acuity, TOUS, MRI, VEP and OCT of the patients were evaluated. With TOUS, bilateral optic nerves were scanned to obtain the axial image showing the optic nerve and the disc in the longitudinal plane.
Results: With TOUS, optic nerve sheath and optic nerve sheath diameter were thickened in affected side compare with unaffected side (p = 0.001 and p = 0.003, respectively). Disease duration inversely correlated with optic nerve diameter (ρ=-0.517, p = 0.040) as well as retinal nerve fiber layer thickness (ρ=-0.831, p < 0.001).
Conclusions: TOUS would be a considerable cost-effective tool for morphological evaluation of the acute ON showing a signifi-cant thickening of the optic nerve and sheath, even though it could explore only limited retrobulbar area.
P-29
A Comparison of Clinical Manifestations of Idiopathic Optic Neuritis in Asian and Western Patients
Lee M, Joo IS
Department of Neurology, Ajou University School of Medicine, Suwon
Background: Idiopathic optic neuritis could be the first manifes-tation of central demyelinating diseases such as multiple sclerosis and neuromyelitis optica, which prevalence are different in ethnic groups. The purpose of this study is to identify whether clinical manifestations of idiopathic optic neuritis are different between in Asian and in Western patients.
Methods: Thirty-seven patients with idiopathic optic neuritis were recruited from May 2013 to April 2018. The mean follow-up period was 11.8 months. We analyzed demographics, clinical symptoms, radiologic findings and prognosis. These data were compared to those of the Western group (Optic Neuritis Treatment Trial).
Results: The mean age of onset was 37.8 years, older than the Western group (37.8 vs. 31.8). Among 37 patients, 25 were female and 12 were male. Female to male ratio was similar by about 2:1 in both groups (67.6% vs. 77.2%). Orbital pain was present in
