KÜÇÜK ÖLÇEKLİ OTEL MUTFAKLARINDA PERSONEL HİJYENİ ve ÖNEMİ
3.4 İLGİLİ ARAŞTIRMALAR
6.1. SONUÇ VE ÖNERİLER
O tratamento com microfraturas, CTMs e PRP-gel (GB) demonstrou os melhores resultados nas análises morfológicas, incrementando de forma importante o aspecto macroscópico e microscópico do tecido de reparação.
A associação de CTMs e PRP-gel é vantajosa no tratamento de lesões condrais, principalmente em relação à organização tecidual e à produção de proteoglicanos. O tratamento com CTMs e PRP-gel aumentou a concentração de IL-1 e PGE2 sinoviais, alterando o ciclo inflamatório articular transitoriamente.
Os tratamentos não foram capazes de influenciar de maneira significativa a produção de colágeno tipo II no tecido de reparação das lesões condrais
Os tratamentos não foram capazes de influenciar de maneira importante os escores de claudicação dos animais
O sucesso do tratamento das CTMs associadas ao arcabouço de PRP-gel provavelmente depende do microambiente onde é implantado e estudos adicionais devem ser realizados objetivando o detalhamento da influência da inflamação articular sob a expressão do potencial das CTMs e do PRP-gel.
O arcabouço de PRP-gel demonstrou boa viabilidade de aplicação cirúrgica, suportando o implante das CTMs, sendo de fácil manuseio e pouco oneroso.
A associação dos tratamentos (microfraturas e células tronco em gel de PRP), a partir dos resultados observados, é indicada em casos de lesões condrais extensas, acompanhadas ou não da inflamação articular.
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