Sonuçlar;
Sıçanlarda bakteriyel enfeksiyonların prenatal-postnatal etkileşimini inceleyen mevcut tez çalışmasında aşağıdaki sonuçlara varılmıştır:
o Prenatal bakteriyel enfeksiyon, yavruların canlı ağırlıklarını düşürmüş, nötrofillerin % oranını yükseltmiş ve lenfositlerin % oranını düşürmüştür ve bu nedenle prenatal bir programlamanın oluşmuştuğu düşünülmüştür;
o Postnatal bakteriyel enfeksiyon, karaciğer ağırlığını, karaciğer indeksini ve TNF-alfa ile IL-1beta düzeylerini yükseltmiştir;
o Prenatal dönemde bakteriyel enfeksiyon geçiren sıçan yavrularının postnatal dönemde tekrar enfeksiyona maruz kalması kortikosteron düzeyini etkilemezken kalp dokusunda SOD düzeyini düşürmüştür.
o Bir diğer ifadeyle bakteriyel enfeksiyonlar prenatal dönemde oluşurlarsa postnatal 60. günde immünolojik savunma hücrelerini etkilerken, sitokinler ve HPG aksında değişikliğe yol açmamıştır. Postnatal bakteriyel enfeksiyonlar ise kısa vadede (4 saat içinde) karaciğer ağırlığı ile sitokinleri artırmıştır.
Öneriler;
Mevcut çalışma, prenatal bakteriyel enfeksiyonların uzun vadede postnatal hayati parametreleri etkileyebileceğini (canlı ağırlık, savunma hücreleri) ve prenatal dönemdeki bakteriyel enfeksiyonların postnatal dönemde oluşan bakteriyel enfeksiyonlarla yanıtı modifiye edebileceğini gösterdiğinden,
o Prenatal ve postnatal dönemlerde ve farklı günlerde yapılması, o Farklı dozları içeren yeni çalışmalar yapılması,
o Canlı ağırlık değişimlerinin detaylı (haftalık) incelenmesi, önerilebilir.
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62
EKLER
EK.1 ÖZGEÇMİŞ
1986 yılında Malatya’da doğdu. Ortaöğretim ve lise eğitimini Malatya’da tamamladı. 2009 yılında Fırat Üniversitesi Sağlık Yüksekokulu Sağlık Memurluğu bölümünden mezun oldu. 2009-2011 yıllarında Hemşirelik yaptıktan sonra 2012 yılında Atatürk Üniversitesinde Araştırma Görevlisi olarak çalıştı, 2013 yılında İnönü Üniversitesi Sağlık Bilimleri Fakültesinde Araştırma Görevlisi olarak atandı, Halk Sağlığı Hemşireliği Anabilim Dalında Yüksek Lisans eğitimini bitirip, 2015 yılında Doktoro eğitimine başladı. 2010 yılında başlamış olduğu Fizyoloji Anabilim Dalında Yüksek Lisansı devam etmektedir. Evli, bir çocuk sahibi ve orta derecede İngilizce bilmektedir.
63
EK.2. ETİK ONAY FORMU
64