Bu çalışmada elde edilen sonuçlar açlığın kognitif fonksiyonlar üzerine olan geliştirici etkisinin AgRP nöronları üzerinden gerçekleştiğini göstermiştir. Bununla birlikte, daha önce yapılan çalışmalarda AgRP hücrelerinin hipokampüse bilinen doğrudan bir projeksiyonu bilinmemektedir. Böyle bir anatomik bağlantı olup olmadığı konusunda ileri çalışmalar yapılabilir. Anatomik bir bağlantı bulunmadığının teyidi durumunda AgRP hücreleri ile hipokampüs arasında fonksiyonel bir bağlantının olabilir mi. Bu muhtemel fizyolojik bağlantı hangi merkezi projeksiyon nöronları üzerinden ilerlemektedir. Son bulgular, dikkatlerin MCH ve oreksinerjik sistem üzerine yoğunlaşmasını sağlamıştır. Ancak AgRP nin uyarılması sonucu ortaya çıkan öğrenme bellek fonksiyonlarındaki iyileşmenin tam olarak hangi mekanizmalar üzerinden olduğu araştırmaya muhtaçtır.
Önceki çalışmalarda açlığa bağlı olarak miktarının arttığı gösterilen BDNF ya da NPY gibi nöroprotektif proteinlerin AgRP nöronlarının uyarısına bağlı değişip değişmediği ikinci bir araştırma konusudur.
AgRP hücrelerinin mekansal öğrenmeye etkileri dışında obje tanıma, zamansal öğrenme, kısa ve uzun süreli bellek ve çalışan hafıza diğer kognitif fonksiyonlarla olan ilişkisi de ortaya konulmalıdır. Kognitif fonksiyonlar dışında açlık uygulamalarında elede edilen metabolik ve periferik etkilerinde düzenlenmesinden sorumlu sinir döngüleri araştırılmaya muhtaçtır.
Besin alımı davranışı insanlarda sadece bir metabolik ihtiyaçla değil sosyal bir besin alımı etkisi de bilinmektedir. Sosyal davranışların hipotalamik bağlantıları üzerine araştırmalar yoğunlaştırılabilir. Yine kronobiyolojinin besin alımın regülasyonundaki etkileri ile AgRP hücrelerinin ilişkisi ortaya konulmaya muhtaçtır.
AgRP hücreleri bu çalışmanın da aralarında bulunduğu bir grup çalışma tarafından besin alımın dışında bir çok kognitif ve metabolik faaliyetlerin kavşak noktasında bulunmaktadır.
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ÖZGEÇMİŞ
Dr. Muhammed İkbal Alp İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesinde lisans eğitimini 2010 yılında tamamladı. Bir süre Şanlıurfa Akçakale’de pratisyen hekim olarak çalıştıktan sonra Konya 112 Ambulans Hizmetleri Komuta Kontrol Merkezinde danışman hekimlik yaptı. İki yıl Selçuk Üniversitesi Tıp Fakültesi yerel etik kurulun üyeliği yanısıra Selçuk Üniversitesi Sinirbilim Araştırlamaları Merkezi yönetim kurulu üyeliği yaptı. 2015 yılından itibaren Medipol Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalında Öğretim görevlisi olarak çalışan Dr. İkbal, Medipol Üniversitesi Genetik Tanı Merkezi müdürlüğü yanısıra Medipol Üniversitesi Geleneksel Tedaviler Araştırma ve Uygulama Merkezi ve Medipol Üniversitesi Reneratif ve Restoratif Araştırmalar Merkezinde açlık ve tokluğun sinirsel bağlantıları üzerine sinirbilim araştırmalarına devam etmektedir. Bilimsel hakemli dergilerde yayınlanmış iki makalesi çeşitli platformlarda bilimsel sunumları bulunmaktadır. Ulusal Fizyoloji Derneği, Türkiye Sinirbilimleri ve Beyin Araştırmaları Derneği yanı sıra Society for Neuroscience üyeliği bulunmaktadır. 13. Ulusal Sinirbilim Kongresi genel sekreterliği ve 15. Ulusal Siribibilim Kongresi düzenleme kurulu üyeliği yanısıra, Hücresel ve Moleküler Sinirbilim çalışma grubu üyesidir. Bu grubun düzenlediği Sinirbilim Günüleri etkinliğinde 3 dönem genel sekterelik yaptı. Türkiyede ilk defa olmak üzere 2015 yılında Medipol Üniversitesi bünyesinde Optogenetik Uygulamalar Kursu düzenledi. 2012 yılından itibaren yüzün üzerinde konferans ve bilimsel etkinlik düzenledi. Doktorasını Selçuk Üniversitesi Fizyoloji Doktora Programında 2017 yılında tamamladı.