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The Antiplatelet activity of ketamine is mediated through suppression of phosphoinositide breakdown and an increase in cyclic GMP.

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Academic year: 2021

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The Antiplatelet activity of ketamine is mediated through suppression of phosphoinositide breakdown

and an increase in cyclic GMP.

許準榕

Chang;Y.;Chen;T.L.;Hsiao;G.;Shen;M.Y.;Lin;K.H.;Chou;D.S.;Lin

;C.H.;Sheu;J.R.

Abstract

In this study, Escherichia coli LPS dose-dependently (100-500 μg/ ml) and time- dependently (10-60 min) inhibited platelet aggregation in human and rabbit platelets stimulated by agonists. LPS also dose-dependently inhibited the intracellular Ca2+ mobilization in human platelets stimulated by collagen. In addition, LPS (200 and 500 μg/ml) significantly increased the formation of cyclic GMP but not cyclic AMP in platelets. LPS (200 μg/ml) significantly increased the production of nitrate within a 10-min incubation period. Furthermore, LPS also dose-dependently inhibited platelet aggregation induced by PDBu (30 nmol/l), a protein kinase C activator. These results indicate that the antiplatelet activity of E.

coli LPS may be involved in the activation of a nitric oxide/cyclic GMP pathway in platelets, resulting in inhibition of platelet aggregation. Therefore, LPS-mediated alteration of platelet function may contribute to bleeding diathesis in septicemic and endotoxemic patients.

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