DNA structure, replication and recombination, DNA organization in chromosome

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DNA structure, replication and recombination,

DNA organization in chromosome

Prof. Dr. İsmail AKYOL Prof. Dr. M. Ali YILDIZ Prof. Dr. M. Muhip ÖZKAN

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Outline of course

• Except in some viruses, DNA serves as the genetic material in all living organisms on Earth.

• According to the Watson–Crick model, DNA exists in the form of a right-handed double helix.

• The strands of the double helix are antiparallel and are held together by hydrogen bonding between complementary nitrogenous bases.

• The structure of DNA provides the means of storing and expressing genetic information.

• RNA has many similarities to DNA but exists mostly as a single-stranded molecule.

• In some viruses, RNA serves as the genetic material.

• Many techniques have been developed that facilitate the analysis of nucleic acids, most based on detection of the complementarity of nitrogenous

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Griffith’s transformation experiment

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Uracil

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γ β α

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Rosalind Franklin

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1 h e lica l tu rn= 3 .4 n m

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Antiparelel Structure

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A, B and Z forms od DNA

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DNA Denaturation

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DNA Denaturation

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DnaA box : 5’ TTATCCACA 3’

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