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CANCER CELL

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Tam metin

(1)

BIO 478

CANCER CELL

(2)

Tümör hücrelerinin yayılım yolları ve yerleşimi

(3)

Metastasis

• Cancer can spread to nearby tissues or to other organs through metastasis.

• Metastasis is the formation of a secondary tumor focus separate from the main tumor.

(4)

Metastasis

• Invasion is not metastasis.

• Malignant neoplasms metastasize through lymphatics, blood vessels and body cavities.

• The tumor that metastasizes is considered strictly malignant.

(5)

• Metastasis through body cavities

• Metastasis through lymphatics

• Hematogenous spread

• Propagation to the veins by invasion

(6)

Tümör Hücrelerinin Yayılım Aşamaları

(7)

• Tumor cells separation E cadherin

β catenin

(8)

• Tumor cells attach to matrix components

excellular matrix proteins such as

laminin and fibronectin

(9)

• Extracellular matrix rupture

• Migration in connective tissue

• Holding onto the vascular basement membrane and exiting the vessel

• Bonding and migration to connective tissue

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