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A concise synthesis of denbinobin. 林建煌 Wang YC;Lin CH;Chen CM;Liou JP

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A concise synthesis of denbinobin.

林建煌

Wang YC;Lin CH;Chen CM;Liou JP

Abstract

A concise synthesis of denbinobin is described via an intramolecular free radical



cyclization and Fremy s salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).

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Denbinobin(1),為一種 phenanthrene quinone 結構的天然物,其最早被發現於 Dndrobium nobile 的成分之中。而最近有報導指出