Lipid Metabolism
Prof. Dr. Zeliha Büyükbingöl
Cholesterol and Steroid Metabolism
Cholesterol is important in cell membranes and is the precursor for bile acids, and all steroid hormones, including vitamin D.
Cholesterol synthesis occurs mainly in the liver, HMG CoA reductase is the rate
limiting enzyme.
Bile Salts and Bile Acids
Bile salts are primarly used to emulsify fats.
Primary bile acids (e.g.,cholic acid,
chenodeoxycholic acid) are synhesized in the liver from cholesterol.
Primary bile acids are conjugated before
secretion in the bile with taurine or glycine.
Keton Bodies
Synthesis of keton bodies occurs mainly in the liver.
Keton bodies are acetone, acetoacetate, and beta-hydroxybutirate.
They are used as fuel by muscle, brain and kidneys.
Adipose Tissue
The Adipocyte as an Endocrine Organ
Adipose tissue
White Adipose tissue (WAT)
Brown Adipose tissue (BAT)
Beige Adipose tissue
Is adipose tissue an endocrine organ?
Adipokines: Adipocytokines include inflammatory
mediators (IL-6, IL-8), angiogenic proteins (VEGF), and metabolic regulators (adiponectin; leptin).
Clinical Correlations
Dislipidemia
Hereditary dyslipidemia
Atherosclerotic vascular disease
Diabetes mellitus
Obesity: Even though statistics showed that people are eating less fat, it was revealed that over the course of the past 20 years the rate of
obesity has been steadily increasing
REFERENCES
Textbook of Biochemistry with Clinical Correlations Ed.TM Devlin 6. ed.
Wiley-Liss, 2006
Principles of Biochemistry DJ Voet, JG Voet, CW Pratt 3. ed. Wiley , 2008
Rapid Review Biochemistry JW Pelley, EF Goljan 3. ed. Elsevier, 2007
