• Sonuç bulunamadı

Aloe-emodin-induced apoptosis in human gastric carcinoma cells

N/A
N/A
Info
İndir
Protected

Academic year: 2021

Share "Aloe-emodin-induced apoptosis in human gastric carcinoma cells"

Copied!
1
0
0

Yükleniyor.... (view fulltext now)

Şimdi indir ( 1 sayfa )

Tam metin

(1)

Aloe-emodin-induced apoptosis in human gastric

carcinoma cells

張君照

Chen SH;Lin KY;Chang CC;Fang CL;Lin CP

摘要

Abstract

The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human gastric carcinoma cell lines, AGS and NCI-N87. We demonstrate that aloe-emodin induced cell death in a dose- and time-dependent manner. Noteworthy is that the AGS cells were generally more sensitive than the NCI-N87 cells. Aloe-emodin caused the release of apoptosis-inducing factor and cytochrome c from

mitochondria, followed by the activation of caspase-3, leading to nuclear shrinkage and apoptosis. In addition, exposure to aloe-emodin suppressed the casein kinase II activity in a time-dependent manner and was accompanied by a reduced

phosphorylation of Bid, a downstream substrate of casein kinase II and a pro-apoptotic molecule. These preclinical studies suggest that aloe-emodin

represents a suitable and novel chemotherapeutic drug candidate for the treatment of human gastric carcinoma.

.

. .

Referanslar

Şimdi indir ( PDF - 1 sayfa - 35.35 KB )

Benzer Belgeler

The purpose of this study was to examine dispositional

Örneğin; Russell (2001), 42 sporcu üzerinde yapmış olduğu çalışmada, optimal per- formans duygu durumunun cinsiyete ve spor tü- rüne (bireysel ve takım sporu) göre

Aloe Vera Mediated Emulgel for Topical Delivery of Desoximetasone

The pH were found in the range of 5.8 to 6.8 and formulation DE3 showed maximum drug content 94.64 0.29 (n=3) as compared to other formulations and therefore used further in

Aloe-emodin-induced apoptosis in human gastric carcinoma cells

The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human

Aloe-emodin-induced apoptosis in human gastric carcinoma cells. Food Chem Toxicol.

The purpose of this study was to investigate the anticancer effect of aloe-emodin, an anthraquinone compound present in the leaves of Aloe vera, on two distinct human

The apoptosis induced by nucleosides in the human hepatoma Hep G2

To investigate the mechanism of apoptosis induced by nucleosides, it was found that the contents of soluble Fas ligand contents were increased in HepG2 cells following I, U, T, and

Induction of Apoptosis in Human Hep G2 Cells

cytotoxicity and therefore whether the two correlate in a cell type-specific manner, Ph cytotoxicity was examined in various cell lines showing different levels of GLUT2

Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells.

In vitro and in vivo studies were performed to assess Ph antitumor activity when combined with paclitaxel (PTX) for treatment of human liver cancer cells.. Inhibition of GLUT2 by

The Effect of Propolis on Aluminum-Induced Genotoxicity in Human Lymphocytes

In view of the great therapeutic interest in propolis and the small number of studies regarding its mechanism of action, the aim of the present study was to evaluate the