Diyarbakır yöresinde tiopurin S-metil transferaz enzim eksikliği ve TPMT*2, *3B ve *3C mutasyonlarının belirlenmesi

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C@ @" - 2 E6 " :" + " C" H + 2 O :6 4 " :66E<" ! -- :66E " 2 #&0) + - -,. F G @6) ,'= 2 -4 ,. J: JC0 JC JC' JC#< 2 - -4 #$, '< + " # ,. 4 /=9) < #&0) ,'= 2 - -2 " 2 D) E;) ':6FB + 8 ? ,. J:@ G) @EC) BD77' 0 3 8 , ,. J:: @6) :C7) 0G@:B 8 B ,. J:6 " 4 ,. J:6 J:@ J::< 4! -- " :66E<" :66G 2 2 2 - + 40 < :@: ,. 2 " ,. J: 8 2 - ,'= + ,. JC0 JC JC' ,'=8=9 , + " :@: 0 2 2 ,. J: JC ,. JC' - O 6"; ,. JC0 - O 6"; O ;7":) S 8 2 4 ,. J@< 2 4 " :66G<"

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CD ! S :667 .0 # 8 /9 2 + - 2 4B H 2 2 < ,. + 2 " 2 ,'= + : %, (Y @E82 Q G82 Q - - #&0) 2 2 ,. J: J:C .0 # 8 /9 .! + " 2 @@E B @@7 H ,. JC' - O E"F O :"F " B 7 ,. J7) 40FC; < H C ,. JE) 4 BEDD0< 2 ,. JE) 7 ,. J7) @6 4! S " :667<" ! :667 L ' ) C66 + C;E # 4 - S < ,. 2 - " ,. J: JC0 JC + " 0 2 - + #&0) - [ - + - " ,'= 2 -2 . ' 2 " # ,. JC0 JC =9 , ,. J: 2 - ,'= 2 - O C) 3 + " 0 - O F"CC #) O D";C " 0 + ,. JC0 2 4! " :667<" :667 ) ,. JC' @6 2 " ! ( " $ ! ( 010 2 2 " $ 010 : -2 + 2 +

CF 2 " $ ,. $, ' + ,. = ,'= " 0 2 ,. J@[JC' 2 + " 010 -2 2 2 + 2 " 2 010 + ,. - 2 2 2 4 " :667<" :667 -N2 ,. 2 2 " D@ + G6 #) 4 - S # < " . 9 2 #&0) - " ,. 2 ,'=8=9 , + " ,'= 2 ,'= 2 2 " 0 + ,. J@[JC' + + G6 # " ,. J@[JC' - O 6"; 4@[@@@< 2 4 " :667<" ! ! :66; ,. ?& = 4 + < + - 2 " L #&0 - ,'= 2 -0 9 #&-0 - G O E) 2 3 ,'= -2 " ! ,. ?& =) C) ;) 2 2 D F + 4! ! :66;<"

CE H 2 :66; 2 ,. 2 - !& , + " L + + #&0) - - " H =&0 .8. 2 #&0 " # ,. ,. J: ,. JC0 ,. JC' ,. + ,'= + 2 -" #&0) 2 " B 2 !& , . 2 Q 2 " !& , CGC6 #&0 2 " 2 * ,. J: ,. JC0 O 6 7 ,. JC' O D @ " 4H 2 " :66;<" H S :66; ,. ,0 2 - 2 2 2 2 " 2 + 2 ,. ,0 2 - " #&0) ,. 4 ,. J: JC0 JC JC'< ,'= ,0 !&,) 4 ;D'^0 V @@:GCFD ?!:a:@0^' V G:G6@6@< ,'=8=9 , " 0 C@D + ,. J@ 4S 8 2< - O ;C"C ,. J: - O 6"E ,. JC0 - O D"7 ,. JC' - O 6"E ,0 O 7@"@ S 8 2 O E"D ;D0 O @@"7 ?!:a:@' - 2 "

CG 2 2 ,. ,0 2 - 2 4H S " :66;<" , :66; 2 ,. ,. 2 - 2 O ;7) - 2 2 2 ,. 2 " , 2 0=.! ,'=8=9 , + H 2 !& 2 4, :66;<" (- :66; 2 % 2 2 ,. " 0 77@ 4 # . < + " B #&0) 2 -- ,'=8=9 , $=. 4 8 < + 2 " ,. J: JC0 JC JC' " 77@ 4FC@ @;D . @FE # < 2 ,. J: ,. JC ,. JC0 - ) O 6"GC . ) O 6"G; # ) OC"@; ,. JC' - . ) O @ F # ) O 6"GF " ,. JC' 4(- " :66;<" 0 :66; 2 % 2 2 ,. 2 - 4 ,. J: JC0 JC JC'< " #&0) - ,. J: 8 2 - ,'= + ,'=8=9 , " 2 @:G 2 " 0 ,. J: - O G"67 ,. JC0 - O :"@7 ,. JC'

C7 - O :"DG 2 " ,. JC 40 " :66;<" H :66; 2 2 2 2 - + 2 ,. J:E) " $ L L ) + ,. JC0 JC' JE ,'=8=9 , + " 9 ,'=80=.! 2 " 2 " ,. J:E " ,. J:E) ;) :67) 49 ) + + < 2 4H " :66;<" ! :66; = 9 ) 2 DDE FD; 2 ,. " 2 + 2#&0) - " ,. 2 G 4 ,. J: JC0 JC JC' JC# JG J7< E 2 - 4 B:C7' B:;: BDE60 BEDD0 E7@B 0G@;B< ,. 2 + " 2 2 ;;F FF 4O F"F< ,. ;D6 4O ;D"F< S 8 2 4 ,. J@[J@< 2 " . 2 - * ,. J@[JC0 4 `DFRO D"F< ,. J@[JC' 4 `7RO 6"7< ,. J@[J: 4 ` :RO 6":< + 4! " :66;<" 9 :6@6 ,. 2 2 B&) + B&

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#&0 - = . &0 , ' 2 &

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D@ ,5<34=3 '=/'$(. &0 , ' 2 & 0 H = ' 8 C: 8 -- -4 S @R 2 H S :R -- S CR. B, S DFR T -- @ S ERT -- : S GRT -- C S 7R( --2 8 C: 2 2 8 = 2 4: @ < , ! 2 8 C: :"6 8 2 = - . &0 , ' 2 ( 8 C: :"6 8 2 ( = - . &0 , ' 2 ( ' 2 8 CF 2 8 (

D: . 3"4 563 I3 )+";# 1 5+43!5 43 I3 )+";# 14"!F1F1 3;A5+5 2 ' K D76 = ,'= 4=/'$( # 0B&/! '< !& , ,. 4 . / / < " + = ,'= + " . ' 3"4 563 3:5!C Z)= )) 2 " = ,'=) 2 - 2 " #&0 - 2 - ,'= 2 - + " ? 2 - 2 2 " I - - 3 " L 2 + 2 + 4, " :66E< = ,'= " + + * cB 2 c? c, 3 2 c#&0 2 c. 2 cH% cH% . =# cB 2 V 8 c0 2 c$ 2 2 4! <"

DC = ,'= - 2 " / - 2 2 -,'= -4$ " :66E<" 9 ,'= - " * @" ! U 8 2 # 0 4 # < + - #&0 - - " d ! B d ( :" ! U 8!2 - , 0 4 # 2 - 2 < #&0 8 2 -2 - - - " d ! 2 4 2 < 4! 2 , - < d $ 2 4$ 2 < 4$ , - < d $ 2 4$ 2 < 4Z) U. )) - < 4T S " :66@< , - - = ,'= " I 0 ' " " 2 2 ' K D76 4=/'$( # < " ;E + 2 + 2 " 0 !& 2 ,. 4 . / / < " 2 2 8 2 - 2 2 4! V , <" 8 2 !&,) + 2 2 " ! 2 , - - -2 " 2 + 2 !&, -" #&0 2 2 - + " , F\ 2 4=< U 4_<

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DF (3?54 ! 2 , 9 !&, ' K ! 2 , B+ " 9 + 2 8 $ - " , -$ 4= 022 ! & :66F< (3?54 ! 2 , 9 4. ' 0 < 5 + - + " L 2 - + - " 0 . , . S 8 2 4= 022 ! :66F<

DE ! 2 2 !&, S 8 2 4 " :666 T S " :66: 9 " :667<" . 5=2+ #J43!K .L& 3"4 563 J52"<F1:" 6)+";# 1 "1"45<43!5151 #"AF46";F G"6" ' = 2 + + 2 2 ,'= " 2 + + I ,. 2 2 4= . Q< - @66b ,'=8 S 4= K< F8@6 Q4N . Q < Q 2 " # " H R $ :/ R@6"D b = Q R@ b 9 #&0 . R: b 4 % #&0 2 < . ' :4:F . < R@"Eb $ R@Fb R ' 9 #&0 . $ , 4=/'$( # < Fb 4

e

DG ,5<34=3 . ,'= Q B " G"6" ;E + ,'= Q ;E) 2 + " # 2 = ,'= 2 2 2 ' K D76 2 2 4. ' . , < 2 " ' + D,5<34=3 E) " ' K D76 2 . ' . , 4. 2 < D,5<34=3 . ,5<34=3 / I3 ,5<34=3 0E) " H !& , ,. - + . , 2 " ( . , + 2 - + : - 2 + 2 - + S 8 2 2 "

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F: 7 #&0 - !& 2 ,. ,'= Q = - 4=/'$( # . / / < + 2 " H $ :6 . ' : =/'$(K 2 2 22 - "

FC . $ ( . ' I3 )+";# 14"!F1F1 3;A5+5 M51 "AF4"1 3"4 563 1"45< 1)M4"!F # 5 $ 3 ;E + 2 ,. ,. J: : ,. JC : ,. JC' 2 " 2 = ,'= ,. J: D ,5<34=3 . ' (3?54 . ' I3 (3?54 . E ,. JC D,5<34=3 . (3?54 . I3 (3?54 . . E ,. JC' D ,5<34=3 . (3?54 . / I3 (3?54 . 0E) " 2 + - D,5<34=3 . . E Z "

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E: ,. J: JC JC' 2 2 * # " 4:66E< ' K = ,'= 2 ,. J: JC0 JC JC' 2 - + ,. JC0) FF C 2 D,5<34=3 . 0E" U " 4:66C< H ,. 2 2 2 = 8 = 8,'= 4 2 ,'=< + "

& " 4:66E< ,. #&08

2 ,. J: JC0 JC' 2 D,5<34=3 . >E" 9 4:6@6< ,. !!', 4 - 2 2 < 0=.! 4 2 - -< $, ' 2 U + " ! " 4:66;< = 9 ) 2 G ,. 2 + 2 O D"F ,. J@[JC0 O 6"7 ,. J@[JC' O 6": - ,. J@[J: 4 ,. JC JC# JG J7< + " ! " 4:66F< 2 #) 4 - S < 2 ,'= + O G"@ ,. 4D ,. JC0 @ ,. J: &`G6< "

EC ,5<34=3 . 0 ' 0 ,. 2 " ,5<34=3 . > #&08 2 ,. " " 4:6@6< % ) 2 ,. ,. J: O :"@E ,. JC0 O @"E7 ,. JC O @"E: ,. JC' O 6"FD " % 2 2 2 % ) ,. ,. JC0 ,. JC' 4(- " :66;<" B 0 2 2 2 + 2 - 4B:7C' BDE60 0G@;B E7@B< O 6"F O F"G O6"7 O 6"C 2 4. " @;;7<" 0- 80 H -@6"@P[ 2 =' 2 2 H - ) ,. JC' 0- 80 ) ,. JC0 4$ " @;;;<" N2 + 2 ,. JC' 2 4$ " :666<" = )

ED ,. JC0 4! " :66;<" 2 ,. J: ,. JC ,. JC' O :"67 2 " 2 ,. - - + " + + 4 ,. -+ - < " 0 + - 2 2 + + " 2 * 2 + ,. 2 " 2 = ,'= + @;D: :@CC #&0 ,. JC ,. JC' " $ ,. ,. " 0 ,. JC ,. JC' + 2 " # + 2 + ,. 2 2 4 " @;;7 ' " :66C= " :66D<"

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EE ,. - 2 4 < 2 4 2 < + 4' S " :66E B " :66D<" 2 2 + = ,'= ,. ,. C # ) + " 2 # ) -,. " 0 = ,'= + " 2 + = ,'= 4 < ,. 2 + 4 U " :66C # " :66E<" + 2 ,. + + - " # ,. 2 + 3 4/ " :66D , " :66G<" ( !0. + + 2 - " !& , ,. 4 ,. J: JC JC' < - 7666 " 9 " 0 - 4 ./ / < - - + " ! 2 # ,. J: JC JC' + - + " 2 2 + + ,. + "

EG D 3!=5E 0 &" ?" 0 ?" T " / ." :66D" = 2 8= . $ 2 2 - 2 !8. - 4 ,. < JC0 JC JC' ' ' F6" 4;<R@F:78@FCD" 0 !" = N" 0 0" , . " N" :66D" / -. ' 2 . - 4 ,. <? R , # -, -$ 2 2 0 S S '0 = 2 " 0 -$ B " E7RC@C8C:C" 0 S . " ' 8# (" !" =" , S =" $" /- 80 3 #" . $" " @;;;" 2 . - 0 0 B , 2 " $ . B " " 7 & " 7R CEG8CG6" 0 . " H !" ! . " & . " $ 3- 0" :66;" ' , 2 ) 0 - 2 !8. - 4 ,. < , 2 " . N " ? " @@ & " C 2 R C@@8C@E" $" 0 0" 0" 3 S " ! . " ! " 9 3 " :667" 0 - 2 !8. - B 2 N 2 , S - S # " . "4DG<R@EDF8@ED7" 0" $ . " 1" . 8= 0" H . " 0" & " :6@6" 9 U - 2 !8 - 4 ,. < !

2 2 " & & & 0 " :;R :CG8:DD"

0" N" . $" " ' 2 $" 0" , S =" $" . S " H" , !" '" @;;7" 2 . - B 2 , 2 8 ! Q 9 0 2 " 0 . " @:; R G@E8G@7" - =" !" !" N" . " (" ' !" :66E" 2 . - 0 ' T 0 2 . , T - S # ' B , " N -022 = " ? " E & " D 2 R :7:8:7G " ( T " (" $ " " ' !" N =" H 9" H 1" H (" " :66@" , 2 - 2 !8. - #

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f 2 " DG47<R@E:D8@E:7" # . " N" # Q " ' '" T 0" ! $" :667" , 2 - 2 2 ' , " N , , = " ? "C7 & "C" (- (" 0 " H &" !2 (" :66;" # - ,. - 2 Q 2 " ( N ' , " EFR :FG8:E:" ( T " (" :66D" , - 2 !8. -2 2 " # . " :ER@7E8@;@"

E; 9 '" $ $" T =" ' N" 9 3 !" H Q N" " $ 0" :66D" 2 !8. - B 2 , 0 2 8 . Q H 2 = 2 " 0 N -2 " DR@7@68@7@G" 9 " " N" #" :6@6" 2 !8 - 4 ,. < 2 2 * 2 S " N ' , " ECR :778:;F" 9 #" . " 9 !" :667" = 8 ,'= ' , ( U 4P @6"C<" B !" N" B =" " . " " (" N" :66F S -2 - 4 ,. < - V S 2 " N ' , " E:RD 2 RDGC8DGE" B 8. '" . " 3 '" " , 0" 9 /" . " 0 (" ?" :66D" , 2 2 - 2 - 9 ' 2 2 R 2 - " ( N ' , " 4E6<R7;8;E" B =" " . " " . " N" ' N" 0" ' 2 " 0" = =" " H . " 0" :66C" 2 !8 - 4 ,. < 2 2 2 2 S -S " 0 , " @7RC;F8D666" $ !" U . " 0 !" , '" 2 N" :66D" , U - ,. 0 B !S , 2 , S - S # " ' ' F6" 4:<R:778:;F $ 0" B" $ ," . " ' !" 0" :66@" -82 U 2 - - 2 - " N" " 2 " . DG" 22R EF8G@" $ !" " $ . " & H" ( &" ( 80 . " . . . &" :66C B 2 - U - ,. &0 : B! !P 0 . #=8 ( 2 2 2 " N ' , FFRFE68EF;"

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f?" :66;" 022 - !& , -- 2 - 2 2 " N . = " 22R F668F6F" H H" $" (" ?" :66G" 0 2 [E8 2 2 Q R

- ,. " 0&&0 ! /9B0! =/(& (=/ /B " :64D<R :F@8:ED" H =" $" B N" " 0 #" 8B N" . " $ " $ &" 9" :66F" - - - S -2 !8 - ,. J@E ,. J@;" , " E;R F:F8F:;" H !" H" " ! '" H" 0S #" '" T " 0" (" N" ,. J:E 4:6798 < ' " N ' , " E7R@[@:68@:C

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

G: & " " ?" 9 /" (" B 0" !" ' 2 &" ?" ! (" ?" . /" 0" :66E" = 2 2 - - 2 !8 - #&08 2 U " ( 2 N -$ B " @DR;;@8;;7" & . " 0" (" /) !" T 2 . " N" . " @;;;" - /- 2 . - 4 ,. <2 2 ' , . 22 ! 2 ( , 0 2 " = " C7RED68EDD" / H"8 " 0 0" $" !" '" :66D" , - 2 - 2 2 2 -S 2 H " = " 4DC<R@FE8@EC" / " & H" H " P H" " . S 0" &" & 3 " " $ =" H" :66F" 2 . - B 2 , 2 ! N 2 , S ! 2 ( " " , " " :74@@<R:@@G8:@@;" / #" . " ! '" " T " '" T =" . " @;;7" $ 2 . - , " N" ' " " @6@ & " FR @6CE8@6DD" , H" & S T " 9 =" H" " &" / T " (" =" :66G" ,. R A" = " DER G:G8G:;" , !" :66;" ,. 2 2 R / 2 -2 " N . = " 2 R DG78D76" = " /" ! N" &" # 2 N" 9" /" /" :66C" 2 - 2 2 S ' ) " 0 , @GREF8E7" = " /" ? " ! N" (" ?" :66D" 2 - 4 ,. < 2 2 8 V 2 S " 2 - ,. 2 2 Q " ( N ' , " 4F;<RG;G876@"

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

2 S - S " & & &

0 " :GR 7CF87C7" ! -- (" " 1 P" . " ( . "! S . " :66@" $ 8 2 B 2 - 2 !8. - # $, ' ' ' " "G & " CRFD78FFF ! 0" ! . " :66;" ' - ,. . 9 ( B 2 - " = N -B " ? " DF & " @ 2 R @:C8 @:G" ! '" 9 S '" B ," B =" . " $ S N" , " T " :66F" . - 2 - 8 2 Q - 2 " &1. N" " @@7 & " @:@6 2 R@8G"

GD ! B" . !" 0" 9 . " ," # B" . &" 9" 9 . " B " ? 0" :66F" ,. 2 - 2 2 - S " # # " CGR;D68;DF" " 0" ! . " H !" $ " S !" ( . " $ #" ! $" H S &" $ . " :66G" 2 !8 -2 2 N 2 2 S " !!& @DG78C::C" " ! " & " :666" B ! 0 . 2 ! 8 & , 2 4!&, < /- 2 !8. - 4 ,. < B " N $ B " DFR:;;8C6:" N" " ! $" H N" ! N" T =" 0 N" ! S H" @;;;" , ' (-- -E8. 2 2

. S ! ' " '0&'(=" ? " 7E & " E" 2 R @6768@67E"

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GF '" =" H (" " 9 . " " " ( T " (" @;;G" . # /- 2 !8. - # - R B 9 0 2 0 . 2 2 " 0 . " @:ER E678E@D" ," T " 9" = . " N" :66E" -2 2 " N ' , " E:[@R CF8DE" 1 N" ," B " " Y 0" " T N" $" T $" $ . " :66D" B - 2 !8 - P ' " ( N ' , " E6R@8C" 1 N" ," 1 !" 9" ' Y" $ . " :66E" # - 8 -- 2 2 - 2 !8 - ' " ' ' 0 CEF" 2 R CCG8CD@" 1 !" :66E" ' , - 2 !8 - " ' ' , " @R @@;8@:7" "

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