Functional importance of epigenetic mechanisms in
genome, and the role in development and disease
etiopathogenesis
Epigenetic Epigenetic
changes in gene expression without changes in gene expression without
change in the genotype
change in the genotype
Epigenetic modifications Epigenetic modifications
•
DNA methylation DNA methylation
•
Histone modifications Histone modifications
•
Chromatin structure Chromatin structure
(chromatin remodeling complexes) (chromatin remodeling complexes)