馬兜鈴酸腎症在純系小鼠的確立與綠茶、

fibers (collagen and

馬兜鈴酸腎病變在組織型態學的特徵為主要損傷於近端腎小管，然而腎絲球形態

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The amount of urinary protein, NAG, BUN, blood sugar were decreased in the BR 300 mg/kg, saikosaponin A, D, P, BR combine with P-treated groups compared with the control group.

The amount of urinary protein, NAG, BUN, blood sugar were decreased in the BR 300 mg/kg, saikosaponin A, D, P, BR combine with P-treated groups compared with the control group.

 Aristolochic acid (AA) dissolved in distilled water (3μg/ml) were administered orally to C3H/He mice (6 weeks, male) as drin king water ad libitum for 4 weeks, control group

測定尿蛋白，N-acetyl-beta-D-glucosaminidase (NAG) 與血中尿素氮 (blood urea nitrogen, BUN)，來評估小鼠腎功能；腎組織使用 PAS

mg/kg/d)及分別投予 CDDP 1, 3, 5 天探討投予次數引起腎毒性的強度，以確立小 鼠 CDDP 腎炎模型。藉由事先投予柴胡濃縮劑(BR 150, 300, 450 mg/kg/d)及其純 成分 saikosaponin