糙米、米麩與精白米對鼠大腸癌前期病變預防效果 之探討

糙米、米麩與精白米對鼠大腸癌前期病變預防效果 之探討

 The purpose of this study was to investigate the effects of brown rice, rice bran and polished ri ce on preneoplastic lesions of colon. F344 rats were fed control diet (C), 40% brown rice diet (BR), 1.1% rice bran diet (LB), 2.2% rice bran diet (MB), 4.4% rice bran diet (HB), 8.9% poli shed rice diet (LR), 17.8% polished rice diet (MR) and 35.6% polished rice diet (HR) and adm inistrated 1,2-dimethylhydrazine (DMH) by i.p. injection. After 17 weeks of experimental peri od, rats were sacrificed and colons were removed to examine for aberrant crypt foci (ACF), m ucin and mucin-depleted foci (MDF). Colonic mucosa was examined for pro-inflammatory cy clooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression. Liver and plasma were examined for thiobarbituric acid reactive substances (TBARS) level. Liver w as examined for superoxide dismutase (SOD), catalase (CAT) activity and glutathione (GSH) l evel. The results showed that rice bran significantly reduced the number of total ACF, total ab errant crypts (AC), ACF containing 1 or 2 crypts and small ACF (P<0.05). Rice bran reduced t he number of large ACF and ACF secreting both sulfomucin and sialomucin (P<0.1). Brown r ice and rice bran significantly reduced COX-2 protein expression of middle colonic mucosa (P

<0.05). Brown rice, rice bran and polished rice did not significantly affect MDF, tumor format ion, plasma and hepatic TBARS level, and hepatic antioxidant-associated parameters. This stu dy indicates that rice bran inhibits colonic ACF formation, pro-inflammatory COX-2 protein e xpression of colonic mucosa and inhibits mucin alteration, suggesting that rice bran has the po tential for deferring colon carcinogenesis.

Preventive effects of brown rice, rice bran and polished rice on preneoplastic lesions of colon in rats

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Diabetic patients are susceptible to peripheral vascular and neurological co

mplications due to long term poor blood glucose control. Injuried wounds i

n such patients are difficult in healing, which is the most common etiology

resulting in amputation. Accoring to prior studies, there are close relations

between wound healing, nutritional status and protein intake. The major pu

rpose of this study is to monitor the nutritional status in diabetic patients co

mbined with foot ulcer, followed by the nutritional influence in patients rec

eived below-knee amputation with further 16 grams protein supply in addit

ion to general diet. The result disclosed the indicators for the nutritional sta

tus in diabetic patients combined with foot ulcer, including hemoglobin, al

bumin, prealbumin and transferrin, were all below reference level, as well

as zinc, the nutrient that associate with wound healing. In patients received

below-knee amputation with additional 16 grams protein supply, the nutriti

onal status before and after the surgery has a trend toward improve but no s

tatistic difference. The possible explanation may be insufficient supplemen

t, short follow up period, low patient numbers and the individual difference

s.