groups showed that allele A is statistically significantly associated with the risk of developing angiodysplasias (χ2 = 13.6; P =.0002; OR = 2.0; 95% CI1, 378–2891). The frequency distribution of the genotypes G/G, G/ A and A/A of rs605143 of the COL4A1 gene was: 54.5%, 35.9% and 9.5% in the group of patients and 72.1%, 23.8% and 4, 1% in the control sample. For the homozygous G/G genotype of this polymorphism, a statistically significant decrease in the risk of angiodysplasias was recorded (χ2 = 11.6; P = .0006; OR = 0.5; 95% CI 0.2971–0.7234). Genotypes with an unfavorable A-allele lead to an increased risk of the formation of angiodysplasias with a high degree of significance.
Conclusions
The rs605143 polymorphism of the COL4A1 gene is a genetic predictor of a hereditary predisposition to pre-cerebral angiodysplasia inUzbek population.
doi:10.1016/j.jns.2019.10.1627
WCN19-1324
Journal of the Neurological Sciences 405S (2019) 105289 Poster Session 4
Sex differences of migraine: Results of a nationwide home-based study in Turkey
N. Karlia, E. Oguz Akarsua, M. Ertasb, M. Zarifoglua, E. Kocasoy Orhanb,
S. Saipc, A. Sivac, B. Baykanb
aUludag University, School of Medicine, Department of Neurology, Bursa,
Turkey
b
Istanbul University, Istanbul Faculty of Medicine, Deparment of Neurology, Istanbul, Turkey
cCerrahpasa University, Cerrahpasa School of Medicine, Department of
Neurology, Istanbul, Turkey Objective
The aim of this study was to compare sex- specific features of migraine and demographic parameters in a nationwide population-based study in Turkey.
Methods
Among 5323 subjects, a total of 871 patients diagnosed as having definite migraine according to the diagnostic criteria of the International Classification of Headache Disorders-III (ICHD-III) were included in our study. The demographic characteristics, associated features, and triggers of migraine were examined with regard to sex.
Results
The study group comprised 640 women (73.5%) and 231 men (26.5%), with a female to male ratio of 2.8:1. Attack duration (p= .006), mean migraine disability assessment scores (MIDAS) (p = .003), frequencies of nausea (p = .001), vomiting (p = .001), osmophobia (p = .001), vertigo/dizziness (pb .001), and allodynia (p = .003) were found significantly different between women and men. When we compared these parameters between men and postmenopausal women, all these parameters were still significant except nausea. Odor was statistically more frequent as a reported trigger in women (p = .03), whereas excessive sleep was a statistically more frequent triggering factor in men (p = .002). The rates of depression and allergy were significantly higher in women when compared with men (pb .001, p = .037, respectively).
Conclusion
Longer attack duration, higher MIDAS scores, and the frequencies of nausea, vomiting, osmophobia, vertigo/dizziness, and allodynia were more significant in women and this variance in sex persisted after menopause. Also, some trigger factors and co-morbidities differ between the sexes. These might result from complex genetic factors besides sociocultural influences and biological differences. Future studies should continue to explore biologic and genetic factors with respect to sex in migraine.
doi:10.1016/j.jns.2019.10.1628
WCN19-1325
Journal of the Neurological Sciences 405S (2019) 105290 Poster Session 4
Comparation between slow frequency quantitative eeg and nihss in acute ischaemic stroke
D. Putri, A. Asmedi, P. Paryono
Universitas Gadjah Mada, Neurology, Yogyakarta, Indonesia Background
In acute phase of stroke, the severity is one of the important output predictors. There is a high correlation between patient clinical improvement and tissue volume surviving in functional tissue (ischemic penumbra). In some studies show that NIHSS is a good predictor of stroke output whereas quantitative EEG is a tool that can be used to assess functional brain that reflects evolution of penumbra.
Purpose
To determine the quantitative EEG suitability with severity of acute ischemic stroke (NIHSS) patient in Sardjito hospital
Method
This study was conducted using observational cross sectional design with Spearman test. The subjects of this study were taken from patients at RSUP Dr Sardjito Yogyakarta in January 2018– March 2018 that has been diagnosed ischemic stroke through anamnesis, physical examination and head CT scan and has been assessed the degree of stroke severity with NIHSS. Performed an absolute power and relative power assessment of qEEG against NIHSS on the subject and for secondary outcomes, we also performed delta alpha ratio (DAR) and delta tetha alpha betha ratio (DTABR).
Result and conclusion
The value of delta and tetha band were not significant but delta alpha ratio (r = 0,419) and delta tetha alpha betha ratio (r = 0,453) were positively correlated with sufficient strength with NIHSS in acute ischaemic stroke patients.
Keyword: Ischaemic stroke, NIHSS, qEEG
doi:10.1016/j.jns.2019.10.1629
