Enhanced S100A9 and S100A12 expression in acute coronary syndrome

Figure 1. Presepsin values between STEMI and controls

Figure 2. ROC curve analysis of presepsin and troponin T

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OP-161 [AJC

» Acute Coronary Syndromes]

Enhanced Serum Levels of Matrix Gla Protein and Bone Morphogenetic Protein in Acute Coronary Syndrome Patients. Zafer Buyukterzi1, Ummugulsum Can2, Mehmet Sertac Alpaydin1, Asuman Guzelant3, Sukru Karaarslan1, Mehmet Mustu1.1Department of Cardiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey;2Department of Biochemistry, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey;3Department of Microbiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey.

Background:Vascular calcification has been found to be associated with increased risk of cardiovascular (CV) morbidity and mortality. Various bone-associated proteins has been suggested to be related with this process. In this study, we aimed to evaluate whether serum levels of bone morphogenic protein-4 (BMP-4) and matrix Gla protein (MGP) differed in patients who were found to have normal epicardial coronary arteries or a culprit lesion in the coronary angiography leading to acute coronary syndrome (ACS).

Methods:Patients admitted to emergency department with the diagnosis of ACS and underwent primary percutaneous coronary intervention between October 2015e April 2016 were consecutively recruited as the patient group. Age and gender-matched subjects who underwent coronary angiography following non- invasive ischemia assessment made the control group.

Results:A total of 90 subjects (63.00
14.02 years, 70% male) were included in this study. MGP (<0.001) and BMP-4 (<0.001) levels were significantly elevated when compared to subjects with normal coronary arteries. Fasting blood glucose (p¼ 0.024), HDL- cholesterol(p¼ 0.002), CRP (p¼ 0.001) levels and LVEF (p¼ 0.021) were significantly corre-lated with serum MGP levels. HDL- cholesterol (p¼ 0.001) and CRP (p¼ 0.030) levels were also significantly correlated with serum BMP- 4 levels. In the model including HDL- cholesterol, CRP, MGP, and BMP- 4, only MGP (odds ratio[OR]: 1.018, p¼ 0.019) and BMP-4 (OR: 1.313, p¼ 0.023) were found to be independently associated with ACS.

Conclusion:This study shows that serum BMP-4 and MGP are inde-pendently associated with ACS occurrence, when adjusted for other CV risk factors. These biomarkers may have a diagnostic potential in ACS patients. Keywords:Matrix Gla protein, bone morphogenetic protein, acute coronary syndrome, biomarker, atherosclerosis.

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OP-162 [AJC

» Acute Coronary Syndromes]

Enhanced S100A9 and S100A12 Expression in Acute

Coronary Syndrome. Zafer Buyukterzi1, Ummugulsum Can2, Mehmet Sertac Alpaydin1, Asuman Guzelant3, Sukru Karaarslan4.1Department of Cardiology, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey;2Department of Biochemistry, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey;3Department of Microbiology and Infectious Diseases, University of Health Sciences, Konya Training and Research Hospital, Konya, Turkey;4_{Department of Cardiology, Ufuk University Faculty}

of Medicine, Ankara, Turkey.

Atherosclerosis is a chronic inflammatory disease of the arterial wall. S100 protein levels had been evaluated in coronary and carotid atherosclerosis in previous studies. In this study, we we aimed to investigate whether serum S100A8, S100A9, and S100A12 levels were markers of acute coronary syndrome (ACS). For this purpose, we compared serum S100A8, S100A9, S100A12 levels between three patient groups; i) those found to have normal coronary arteries in cor-onary angiogram, ii) those diagnosed with stable corcor-onary artery dis-ease, and iii) those who presented with acute coronary syndrome. A total of 90 patients[63.00(56.00-73.00)years,62.89% male] who un-derwent coronary angiography and/ or percutaneous coronary inter-ventions(PCI) between June 2015-October 2015 have been included. None of the groups differed from each other regarding baseline char-acteristics(p>0.05). S100A9 levels were elevated in ACS when compared with the normal coronary arteries (p¼0.033). S100A12 levels were found to be elevated in acute coronary syndrome when compared to both patients with normal coronary arteries and stable coronary artery disease (p¼0.001). S100A8 levels did not show significant difference among groups. S100A12 was identified as an independent associate of acute coronary syndrome (p¼0.049). These results suggest that S100A12 may serve as a marker of coronary plaque instability, and may have a therapeutic implications in ACS treatment.

Keywords:S100 proteins, atherosclerosis, acute coronary syndrome.

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OP-163 [AJC

» Preventive cardiology]

Comparison of Resistance Rate in Coronary Artery Patients With Antithrombotic Treatment. Gizem Türkel, Fatma Taneli, Ali Rıza Bilge, Hakan Tıkız. Department of Cardiology, Celal Bayar University, Manisa, Turkey.

This study aimed to measure drug resistance and frequency of resistance development using the Multiplate electrode aggregometry (MEA) in patients who were diagnosed with coronary artery disease and used acetylsalicylic acid (ASA), clopidogrel, prasugrel, and ticagrelor at least for 6 months. This study also aimed to investigate the relationship

MARCH 23e26, 2017

The American Journal of Cardiologyâ _{MARCH 23e26, 2017 13}th_{INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY}

AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral

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