Akut gastroenterit ön tanılı hastalarda campylobacter türlerinin yeri ve antimikrobiklere duyarlılıklarının araştırılması

T.C.

AKUT GAS

CAMPYLOBACTER

ANT

T.C.

AKUT GAS

CAMPYLOBACTER

ANT

ii Campylobacter

.

-iii ... v ... ... ... ... 1 ... ... ... 3 ... 5 ... ... ... 9 Campylobacter ... ... ... ... ... ... ... ... ... ... ...25 ... ... ... ... ... ... ... ... ...

iv ... ... ... ... ... ... ... ...32 ... ... ...33 ...39 ...46 ...47 ...54

v : : AGE : : : : : :Campylobacter jejuni : : 2 : : -: : : : 2S 2O2 : : - : - - - :

vi : RNA : rRNA : :T :

vii Campylobacter Campylobacter . -Campylobacter . Campylobacter C -Campylobacter . - -. . Campylobacter Salmonella

Shigella . Campylobacter Campylobacter jejuni

Campylobacter coli . Campylobacter . Campylobacter . Campylobacter Campylobacter . Campylobacter

viii Campylobacter -2016 Campylobacter - Campylobacter Campylobacter -. Campylobacter . -Campylobacter Salmonella. Shigella

Campylobacter jejuni Campylobacter coli.

Campylobacter Campylobacter Campylobacter Campylobacter . Campylobacter

ix .1. 3 .2. .3. Campylobacter .4. Campylobacter .1. Campylobacter .2. Campylobacter 3 3.1. 3 3.1. 33 3.2. Campylobacter Salmonella .2. Campylobacter Salmonella .3. 35 .3. Campylobacter 3 .4. Campylobacter 3 .5. .6. .4. Campylobacter 3

1

-

-Campylobacter, Salmonella Shigella

2 .

Campylobacter, Salmonella, Shigella

-1.2. - - 3 ]. Enterobacteriaceae Bacteroides -Staphylococcus . Corynebacterium . Bifidobacterium

Bacteroides, Clostridium, Peptostreptococcus, Bifidobacterium ve Eubacterium Escherichia coli

1.1

-3 . 1.1. . O Bacteroides fragilis Bacteroides . Fusobacterium . Lactobacillus spp -Clostridium perfringens -35 Clostridium . -35 Peptostreptococcus . Peptococcus pp. Staphylococcus aureus -Enterococcus . -Escherichia coli Klebsiella . -Enterobacter . 5-55 Proteus p. 3-Salmonella enteritidis 3-Shigella - -Pseudomonas aeruginosa 3-Candida albicans -Campylobacter Campylobacter

-4 1.2.1. -. - . A

-5 1.2.2. p . 1.2.2.1. . . E. coli

6 1.2.2.2. . Shigella Shigella Salmonella . 1.2.3. .2. .2. -Campylobacter . Salmonella . Shigella . E E.coli Clostridium difficile Yerisinia enterocolitica Entemoeba histolytica Cryptosporidium . Cyclospora Giardia lamblia

7 Campylobacter,

Salmonella, Shigella, Yersinia Clostridium difficile .

- .

1.2.3.2.

.

8 .

1.2.4.

Salmonella, Shigella Campylobacter

1.2.4.1.

-.

1.2.4.2.

Salmonella, Shigella, Campylobacter, Yersinia

.

9 E. histolytica 1.2.4.3. . 1.2.5. . .

10 .

1.3. Campylobacter

1.3.1.

11 Campylobacter’ Vibrio Vibrio fetus Vibrio jejuni Vibrio jejunum Campylobacter . . Campylobacter’ Vibrio fetus . Vibrio Related Vibrio Vibrio’ Campylobacter . 1.3.2. Campylobacter’ V. fetus Vibrio bulbulus Campylobacter sputorum

Vibrio Campylobacter

12

V. jejuni V. coli Campylobacter

. ) -Proteobacteria NA . Campylobacter’ Campylobacteraceae Campylobacter

Arcobacter Sulfurospirillum Campylobacter’ler

Campylobacter jejuni Campylobacter coli Campylobacter upsaliensis C. fetus

1.3.3

Campylobacter -

5-C. hominis

-.

Campylobacter’ Campylobacter gracilis

Campylobacter

-13 Campylobacter -Camplobacter’ .3. .3. Campylobacter . 2S NA C. jejuni subsp. jejuni - - S C. jejuni subsp. doylei - - S S C. coli - - S C. upsaliensis - - - S S C. fetus subsp. fetus - - - S S C. lari - - -C. hyointestinalis - - - S C. concisus - - - -C. sputorum - - - S * Campylobacter - C -. C-. jejuni C. coli 55 -. 1.3.4. Campylobacter Campylobacter

14 Campylobacter Campylobacter . C. jejuni Campylobacter .4. . Campylobacter . .4. Campylobacter .

C. jejuni subsp. jejuni C. jejuni subsp. doylei C. coli C. fetus C. upsaliensis C. lari C. hyointestinalis C. helveticus -C. sputorum C. concisus C. curvus C. rectus C. showae C. gracilis C. mucosalis -* -:

15

Campylobacter C. jejuni C. coli

Salmonella, S. aureus Campylobacter’ Campylobacter Campylobacter -Campylobacter Campylobacter Campylobacter’ Campylobacter’ Campylobacter’

16 Campylobacter’ . -C. jejuni . Campylobacter ceu - . -C. jejuni 1.3.5. Campylobacter

17 - . C. concisus, C. rectus C.curvus C.showae . Campylobacter Campylobacter Campylobacter’ Campylobacter’ Campylobacter’ Campylobacter Salmonella Campylobacter’ Salmonella .

18 Campylobacter -Campylobacter . Campylobacter’ Campylobacter Campylobacter Campylobacter’ -Campylobacter -Campylobacter Campylobacter .

19 Campylobacter C. jejuni Campylobacter Campylobacter Salmonella Shigella Campylobacter -Campylobacter C. jejuni C. coli Campylobacter Campylobacter 3 Campylobacter Campylobacter . Campylobacter Campylobacter -Campylobacter Campylobacter

20 Campylobacter -1.3. Campylobacter

C. jejuni C. coli C. upsaliensis

Salmonella Shigella . Campylobacter Campylobacter -C. jejuni - -- Camplobacter C. jejuni .

21 1.3.

1.3.

Campylobacter

C. fetus, C. jejuni C. upsaliensis

-Campylobacter’ 1.3. Campylobacter Campylobacter’ Campylobacter’ -Campylobacter’

22 1.3.7.3.

C. jejuni C. coli C. upsaliensis

. Campylobacter -1.3.7.4 Campylobacter ( ) - . 1.3.7.5. Campylobacter’

-23 1.3.7.6. Campylobacter’ Campylobacter’ Campylobacter Campylobacter’ -1.3.8. Campylobacter Campylobacter’ C. jejuni . . Campylobacter C. jejuni C. coli

24 Campylobacter C. coli C. jejuni -C. fetus 1.3.9. Campylobacter Campylobacter’

25 2. 2.1. T -. 2.2. -) N . - -C E

26 2.3. 2.3.1. -2.3.2. -2.3.

27 S 3 2.3.4. . 2.3.5. E p -. K

28 2.3.6. -p-. -. 2.3.7. 9 . 2.3.8. . -.

29 2.3.9. . K 2.3.10. -. 2.3.11. . -. 2.4. Campylobacter .

30 Campylobacter . .1. . . Campylobacter . C. jejuni C. coli -C. lari - -- ) . 2.5. Campylobacter .2 . .2. Campylobacter . C. jejuni > > > C. coli > > > - - .

31 .

32 3 3 -. -3.1. .1. 3 Campylobacter Salmonella

33 Shigella 3.1. .1. Sulu K- * Y-K** Campylobacter 9 42 Salmonella 3 - 25 9 67 * K- -Campylobacter Salmonella 3

Campylobacter C. jejuni C. coli

. Campylobacter Salmonella C. coli .2. Campylobacter Salmonella Campylobacter Salmonella

34 3.2. Campylobacter Salmonella Campylobacter Salmonella -3-5 5 - 9 -3 5 42 25 67 100 .2. Campylobacter Salmonella 3.3.

35 .3. Campylobacter Salmonella 3 5 3 3 * 9 3 42 25 67 * Campylobacter -.3 .4. .5. .6. C. jejuni C. coli Campylobacter C. jejuni C. coli

36

.3. Campylobacter

.4. Campylobacter

37 .5. * .6. Campylobacter C. coli Campylobacter Ç .4.

38 .4. Campylobacter C. jejuni 39 C. coli Salmonella

-39 4 - -Campylobacter, Salmonella Shigella Salmonella Shigella S Campylobacter’ Campylobacter’ Campylobacter Campylobacter

40 Salmonella Salmonella Campylobacter Campylobacter -Campylobacter Campylobacter Campylobacter Campylobacter Campylobacter -Campylobacter Campylobacter Salmonella Campylobacter’ Salmonella Campylobacter’ Salmonella Shigella

41

-Campylobacter Salmonella Shigella

- Campylobacter Campylobacter -. Shigella -Salmonella - Campylobacter – . Campylobacte -- -Campylobacter Salmonella Campylobacter C. jejuni -Campylobacter’ C. jejuni Campylobacter C. jejuni Campylobacter C. jejuni C. coli Campylobacter C. jejuni, C. coli Campylobacter Campylobacter -

-42 Campylobacter Campylobacter -Campylobacter - -Salmonella -Campylobacter -Campylobacter Campylobacter -Campylobacter Campylobacter -Campylobacter - Salmonella - Campylobacter Salmonella Campylobacter

43 Campylobacter C. jejuni C. coli C. lari C. jejuni C. coli Campylobacter Campylobacter Campylobacter -Campylobacter Campylobacter Campylobacter Salmonella Campylobacter Campylobacter K

44 Campylobacter -Campylobacter -Campylobacter . Campylobacter Salmonella Campylobacter . -Campylobacter Campylobacter

45 Campylobacter -Campylobacter’ -Campylobacter Campylobacter

46 5. -Campylobacter, Salmonella -- .

Campylobacter C. jejuni C. coli

Campylobacter -Salmonella -Campylobacter Campylobacter Campylobacter Campylobacter .

47 6. -Campylobacter - -Campylobacter -Campylobacter jejuni -35. - Campylobacter . -9. Campylobacter jejuni - – -. -Campylobacter jejuni -9. . Campylobacter jejuni -Campylobacter jejuni -55. -. , –5. Campylobacter upsaliensis

-48 - -. Campylobacters , -Campylobacter jejuni -- . . Campylobacter -Campylobacteracea. Campylobacter. -Campylobacter: 9 – - . -Campylobacter , -9 -5. - . Campylobacter -ampylobacter -- . Campylobacter jejuni -Campylobacter Arcobacter

933-Campylobacter Arcobacter Manual of Clinical Microbiology

-99.

Campylobacter jejuni. :

-99.

Campylobacter Arcobacter Helicobacter

-49

-. Campylobacter

-Campylobacter jejuni Campylobacter coli.

, 39:

-Campylobacter jejuni Campylobacter coli

-55.

--3 .

Campylobacter Jejuni Campylobacter Coli’n

T.C -ampylobacter jejuni. –9. -– -. Campylobacter jejuni Campylobacter upsaliensis –9. – Campylobacter jejuni – Vibrio jejuni , – . Campylobacter -Salmonella-Shigella -. Campylobacter – –

Vibrio fetus J Infect Dis,

-Campylobacter

50 - . . Campylobacter jejuni C. coli - 39-. Campylobacter jejuni/coli Escherichia coli , -93. Campylobacter jejuni - . - . Campylobacter -- -9. -Campylobacter jejuni – Campylobacter jejuni -Campylobacter jejuni Campylobacter coli -– Campylobacter. -Campylobacter jejuni , -. Campylobacter - -5. -. Campylobacter jejuni p. -Campylobacter -555– -, -53.

51 - -Campylobacter jejuni Campylobacter. – - -. Campylobacter A , -Salmonella . Campylobacter -Campylobacter -- --39.

Campylobacter jejuni Campylobacter coli

-5. Campylobacter – – - - -Campylobacter jejuni -3. . Campylobacter , 35 -. Campylobacter – Campylobacter. C -- - . Campylobacter T -Campylobacter -Campylobacter –3. -Campylobacter jejuni

-52 -Campylobacter jejuni -Campylobacter -. Campylobacter , -Campylobacter Campylobacter – V.fetus . , – Campylobacter --53. -- Campylobacter –5. Campylobacter jejuni -- -Campylobacter jejuni -Campylobacter - -Campylobacteraceae. -5. -– Campylobacter Campylobacter fetus . -Campylobacter

-53 Campylobacter jejuni -Campylobacter -9. W -N -Campylobacter -Campylobacter jejuni: -93. Campylobacter -Campylobacter -3.

54 7. : :T.C. : : E- :