Vahdet-i Vücut, Vahdet-i Mevcut ve Panteizm

Neste estudo, demonstramos que o protocolo de indução de diferentes estressores cronicamente resultou em alterações comportamentais como prejuízos na evocação e extinção de uma memória aversiva, porém sem afetar o processo de aquisição de ratas. Além disso, o protocolo se mostrou eficaz em eliciar mudanças fisiológicas como o aumento dos níveis de corticosterona plasmática.

O estudo também mostrou o envolvimento do ciclo estral nos diferentes processos mnemônicos. Neste sentido, é sugerido que as oscilações hormonais nas diferentes fases do ciclo estral de ratas podem influenciar diferentemente os processos de consolidação, evocação e extinção da memória aversiva da tarefa de Esquiva Discriminativa em Labirinto em Cruz Elevado, além de promover ações neuroprotetoras em relação a diferentes agentes estressores.

A tarefa de Esquiva Discriminativa em Labirinto em Cruz é um excelente modelo de aprendizagem e memória capaz de estudar as alterações promovidas pelo estresse. O modelo pôde avaliar simultaneamente os parâmetros de aprendizagem, memória, ansiedade e atividade lomocotora.

Contudo, por limitação do protocolo utilizado, não foi possível mensurar os níveis de hormônios sexuais no momento da aquisição e evocação da tarefa, assim como investigar possíveis alterações estruturais e neuroquímicas como aumento de fatores neurotróficos em regiões do hipocampo.

Por fim, mais estudos são necessários para esclarecer aspectos ainda pouco compreendidos sobre os mecanismos deletérios ou positivos do

78 estresse sobre os processos mnemônicos. Além de esclarecer os possíveis os mecanismos envolvidos na neuroproteção promovida por hormônios sexuais em relação aos déficits de memória promovidos pelo estresse.

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