Bu çalışmada diklorglioksim bileşiğinden yola çıkılarak kinolin içeren yeni oksim ligandı ve bunların Cu(II) ve Ni(II) kompleksleri sentezlenmiştir. Sentezlenen ligand ve komplekslerin yapıları 1H-NMR, 13C-NMR ve FT-IR çalışmaları ile aydınlatılmıştır. Çalışmanın son kısmında sentezlenen ligand ve komplekslerin in-vitro antibakteriyel etkileri “Disk Difüzyon Yöntemi” kullanılarak incelenmiştir. 3 adet gram-pozitif (Staphylococcus aureus ATCC 29213, MRSA Staphylococcus aureus ATCC 43300, VRE Enterococcus faecalis ATCC 51299) ve 3 adet gram-negatif (
Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Salmonella
enteritidis ATCC 13076 ) olmak üzere 6 mikroorganizma ile çalışılmıştır.
Sentezlenen ligand ve komplekslerin potansiyel biyoaktif özellikleri nazokomiyal patojenler olarak bilinen ve antibiyotiklere direnç kazanma potansiyelleri yüksek olan bir dizi gram negatif ve pozitif bakteri üzerinde denenmiştir. Sonuçlar incelendiğinde ilginç olarak ligand ve Cu(II) kompleksinin etkisiz yada düşük etki göstermesine rağmen Ni(II) kompleksinin kayda değer etki gösterdiği bulunmuştur. Ni(II) kompleksi bütün bakterilere karşı 13 mm zon çapı üzerinde etki göstermekle birlikte özellikle Escherichia coli’ye 18 mm zon çapı ile kontrol antibiyotiklerinin üzerinde etki göstermiştir.
Nikel kompleksinin gösterdiği bu ilginç antibakteriyel özellik, daha kapsamlı çalışmaların yapılması için teşvik edicidir.
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EĞİTİM
Derece Adı, İlçe, İl Bitirme Yılı
Lise : ZEKİ ÖZDEMİR LİSESİ, MERAM, KONYA 2007
Üniversite : KIRIKKALE ÜNİVERSİTESİ, YAHŞİHAN,
KIRIKKALE 2014
Yüksek Lisans : SELÇUK ÜNİVERSİTESİ, SELÇUKLU, KONYA 2020 Doktora :
İŞ DENEYİMLERİ
Yıl Kurum Görevi
2016-2019 TEDEM KOLEJİ, KONYA FEN BİLİMLERİ ÖĞRETMENİ 2019- SÜLEYMAN UĞUR SITKI ORTAOKULU, HAKKARİ FEN BİLİMLERİ ÖĞRETMENİ
UZMANLIK ALANI YABANCI DİLLER
BELİRTMEK İSTEĞİNİZ DİĞER ÖZELLİKLER YAYINLAR