NMR spektroskopisi, GC ve GC-MS spektroskopisi ile belirlendi.

Şekil 4.2.1. Hidrojen transfer katalitik sistemi

Çizelge 4.2.1 Keton ve aldehitlerin iso-PrOH içerisinde 3a-c kompleksleri ile

indirgenmesi

Deney No Katalizör Substrat a Dönüşüm %

1 3a 4-kloroasetofenon 100

2 3b 4-kloroasetofenon 97

3 3c 4-kloroasetofenon 92

5 3b 4-Metilasetofenon 10 6 3c 4-Metilasetofenon 89 7 3a Asetofenon 93 8 3b Asetofenon 96 9 3c Asetofenon 89 10 3a Siklohekzanon 100 11 3b Siklohekzanon 100 12 3c Siklohekzanon 100 13 3a 4-klorobenzaldehid 100 14 3b 4-klorobenzaldehid 100 15 3c 4-klorobenzaldehid 100 16 3a 4-Metilbenzaldehid 100 17 3b 4-Metilbenzaldehid 100 18 3c 4-Metilbenzaldehid 100 19 3a 4-kloroasetofenon 93c 20 3b 4-kloroasetofenon 97c 21 3c 4-kloroasetofenon 90c 22 3c 4-kloroasetofenon 14d 23 3b 4-kloroasetofenon 19d 24 3a 4-kloroasetofenon 1e

25 3b 4-kloroasetofenon 3e

26 3c 4-kloroasetofenon 1e

27 3c 4-kloroasetofenon 65b

28 Katalizör yok 4-kloroasetofenon 20f

29 Katalizör yok Asetofenon 15f

30 Katalizör yok Siklohekzanon 30f

a_{Reaksiyon şartları: Reaksiyonda kullanılan substrate/catalyst/base(S/C/base) molar} oranı (1 : 0.0075 : 4), i-PrOH (5 mL), KOH (4 mmol), 3a-c (0.0075 mmol), 80 o

C, 30 dakika. Dönüşümler GC and GC-MS ile belirlendi. (Her bir reaksiyon 3 kere tekrarlandı. b

Normal atmosferik koşullarda kurutulmamış 2-propanol kullanıldı, c 0.00375 mmol katalizör konsantrasyonu kullanıldı, d at 50 oC, e oda sıcaklığı, f katalizör kullanılmadı

5-SONUÇ

Bu çalışma sonucunda değişik sterik ve elektronik özelliklere sahip 5 farklı NHC öncülü (1a-e) ve bu öncüllerden sentezlenen Ag-NHC (2a-e) ile Ru-NHC kompleksleri (3a-e) sentezlenmiştir. Sentezi gerçekleştirilen Ru-NHC komplekslerinin C-H aktivasyon deneylerindeki aktiviteleri araştırılmış ve literatürde var olan çalışmalar ve katalizör sistemleri ile karşılaştırmaları yapılıp aktivite göstermediği görülmüştür. B planı olarak bu sentezlenen komplekslerin hidrojen transfer deneylerindeki aktiviteleri araştırılmış ve oldukça iyi sonuçlar elde edilmiştir. Elde edilen sonuçlar literatüre göre oldukça iyi ve tatminkârdır. Bu çalışma sonucunda elde edilen bulgular kısa sürede yayınlanacaktır. Sentezi gerçekleştirilen Ag-NHC komplekslerinin ise değişik medikal uygulamalarda gösterebileceği aktivitelerin incelenmesi ileriki günlerde yapılacak ve sonuçlar tatminkâr olması durumunda yayımlanacaktır.

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