Novos estudos com diferentes doses e tempo de aplicação do rhG-CSF, ciclofosfamida e combinações entre estas devem ser realizados no intuito de encontrar a melhor dose para cães para mobilização de células CD34+ da medula óssea para o sangue periférico para posterior realização de transplantes de sangue periférico mobilizado em cães.
8. REFERÊNCIAS6
ATKINSON, K. Therapeutic Decision Making in Marrow Transplantation for Non- Hodgkin’s Lymphoma. In: ________ BMT Data Book: A Manual for Bone Marrow and Stem Cell Transplantation. New York: Cambridge University Press, 1998. cap. 8. p.108-149.
BARRINGTON, G. M. et al. Chronic weight loss in an immunodeficient adult llama. Journal of the American Veterinary Medical Association, United States, n. 211, p. 294-298, 1997.
BENDER, J. G. Defining a therapeutic dose of peripheral blood stem cells. Journal of Hematotherapy, New York , v.1, n. 4,p.329-341, 1992.
BENJAMIN, S. Introduction. In: TRELEAVEN, J. & WIERNIK, P. Color Atlas and Text of Bone Marrow Transplantation. London:Mosby-Wolfe, 1995. cap. 1, p. 9-17.
BESINGER, W. et al. Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor. Blood, v. 81, n. 11, p. 3158-3163, 1993.
BONONI, A. et al. Predictive value of hematological and phenotypical parameters on postchemotherapy leukocyte recovery. Cytometry part B (clinical cytometry), United States, v. 76B, p. 328-333, 2009.
BRAVO, L. et al. Serum granulocyte colony-stimulating factor (G-CSF) and interleukin-1 (IL-1) concentrations after chemotherapy-induced neutropenia in normal and tumor bearing dogs. Experimental Hematology, v.24, n.1, p.11- 17, 1996.
6ASSOCIAÇÃO BRASILEIRA DE NORMAS TÉCNICAS. NBR-6023: Informação e documentação, referências, elaboração. Rio de Janeiro,
BROXMEYER, H. E. et al. Human umbilical cord blood as a potencial source of transplantable hematopoietic stem/progenitor cells. Proceedings of the National Academy of Sciences of the United States of America, Washington, v.86, p.3828- 3832, 1989.
BRUNO, B. et al. CD34+ selected bone marrow grafts are radioprotective and establish
mixed chimerism in dogs given high dose total body irradiation. Transplantation, Baltimore, v.68, n.3, p.338-344, 1999.
CÁPUA, M. L. B. et al. Autologous bone marrow transplantation in a dog with lymphoma: a clinical study. Ciência Rural, Santa Maria, v.39, n.2, p.580-584, 2009a.
CÁPUA, M. L. B. et al. T lymphocyte subsets of the umbilical cord blood of dogs. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 61, n. 4, p. 791-796, 2009b.
CARTER, R. F.; VALLI, V.E. Advances in the cytologic diagnosis of canine lymphoma. Seminars in Veterinary Medicine Surgery (Small Animal), v.3, n.2, p.167-175, 1988.
CHAN, A. et al. Impact of colony-stimulating factors to reduce febrile neutropenic events in breast cancer patients receiving docetaxel plus cyclophosphamide chemotherapy.
Support care cancer. Alemanha, Disponível em:
<http://www.springerlink.com/content/e608n0l238866261/fulltext.pdf>. Publicado em 17 de março de 2010. Acesso em 14 de abril de 2010.
CHUN, R. et al. Cancer chemotherapy. In: WITHROW, S.J.; MACEWEN, E.G. Small Animal Clinical Oncology. 3.ed. Philadelphia: Saunders, 2001. Cap.9, p.92-118.
COUBAN, S. et al. Bone marrow mobilized with granulocyte colony-stimulating factor in related allogeneic transplant recipients: a study of 29 patients. Biology of Blood and Marrow Transplant, Toronto, v. 6, n. 4 p. 422-427, aug 2000.
COUTO, C. G. Management of complications of cancer chemotherapy. Veterinary Clinics of North America – Small Animal Practice, v.20, n.4, p.1037-1053, 1990.
COUTO, C. G.; HAMMER, A. S. Afecções dos linfonodos e baço. In: ETTINGER, S.J.; FELDMAN, E.C. Tratado de Medicina Interna Veterinária. São Paulo: Manole, 1997. cap.144, p.2667-2689.
COUTO, C. G. Complications of cancer chemotherapy. In: NELSON, R.W.; COUTO, C.G. Small Animal Internal Medicine. 3.ed. St.Louis: Mosby, 2003. Cap.80, p.1108- 1116.
COUTO, C. G. Oncologia: princípios de tratamento do câncer. In: NELSON, R. W.; COUTO, C. G. Medicina Interna de Pequenos Animais. 3 ed. Rio de Janeiro: Guanabara Koogan, 2006. cap. 78, p. 864-869.
DALECK, C. R.; DE NARDI, A. B.; RODASKI, S. Oncologia em cães e gatos. São Paulo: Roca, 2008, 612p
DE KOK, I. J. et al. Investigation of allogeneic mesenchymal stem cell-based alveolar bone formation: preliminary findings. Clinical Oral Implants Research, Copengahen, v. 14, n. 4, p. 481-489, 2003.
DOBSON, J. M. Classification of canine lymphoma: a step forward. The Veterinary Journal, London, v.167, p.125-126, 2004.
DÜRSHEN, U. et al. Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood, Victoria, v. 72, n. 6, p. 2074-2081, 1988.
EICHACKER, P. Q. et al. Cardiopulmonary effects of granulocyte colony-stimulating factor in a canine model of bacterial sepsis. Journal of Applied Physiology, v.77, n.5, p. 2366-2373, 1994.
ETTINGER, S. N. Principles of treatment for canine lymphoma. Clinical Techniques in Small Animal Practice, Philadelphia, v.18, n.2, p.92-97, 2003.
FALDYNA, M. et al. Lymphocyte subsets in peripheral blood of dogs – a flow cytometric study. Veterinary Immunology and Immunopathology, Amsterdam, v. 82, n. 1-2, p. 23-37, 2001.
FAN, T. M. Lymphoma updates. The Veterinary Clinics of North America – Small Animal Practice, Philadelphia, v.33, n.3, p.455-471, 2003.
FAN, T. M.; KITCHELL, B. E. An update on diagnosing and treating canine lymphossarcoma. Veterinary Medicine, p.58-67, 2002.
FARIA, R. L. et al. Quimioterapia intensiva com suporte hematopoiético autólogo em doentes com carcinoma de mama, Acta Médica Portuguesa, v. 17, n. 1, p. 35-41, 2004.
FELDMAN, B. F. et al. Schalm’s veterinary hematology. 5.ed. Philadelphia: Lippincott Willians & Wilkins, 2000. 1344p
FOURNEL-FLEURY, C. et al. Cytohistological and immunological classification of canine malignant lymphomas: comparison with human Non-Hodgkin’s lymphomas. Journal of Comparative Pathology, Edinburgh, v. 117, p.35-39, 1997.
FRÁGUAS, M. S. Estudo de casos de linfoma canino, ocorridos entre maio de 2003 e dezembro de 2006, junto ao Hospital Veterinário “Governador Laudo Natel” da FCAV-UNESP-Jaboticabal. 2008. 64f. Trabalho de Graduação (Bacharel em
Ciências Biológicas) - Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal – Universidade Estadual Paulista, São Paulo.
FRUEHAUF, S.; SEGGEWISS, R. It’s moving day: factor affecting peripheral blood stem cell mobilization and strategies for improvement. British Journal Hematology, v. 122, n. 3, p. 360-375, 2003.
FRIMBERGER, A. E. et al. A combination chemotherapy protocol with high dose intensification and autologous transplant (VELCAP-HDC) for canine lymphoma. Journal of Veterinary Internal Medicine, Philadelphia, v.20, n.2, p.355-364, 2006.
FULTON, R. et al. Effect of recombinant human granulocyte colony-stimulating factor on hematopoiesis in normal cats. Experimental Hematology, Copenhagen, v. 19, p. 759- 767, 1991.
GASPER, P. W. The hemopoietic system. In: FELDMAN, B.F.; ZINKL, J.G.; JAIN, N.C. Schalm´s Veterinary Hematology. Philadelphia: Williams & Wilkins, 2000. cap. 11, p. 63-68.
GASPER, P. W & THRALL, M. A. Hematopoietic Stem Cell Transplantation. In: FELDMAN, B.F.; ZINKL, J.G.; JAIN, N.C. Schalm´s veterinary hematology. Philadelphia: Williams & Wilkins, 2000. cap. 17, p. 97-101.
GENGOZIAN, N. Identification and isolation of hemopoietic progenitors. In: FELDMAN, B. F.; ZINKL, J. G.; JAIN, N. C. Schalm´s veterinary hematology. Philadelphia: Williams & Wilkins, 2000. cap.16. p. 91-96.
GLUCKMAN, E. et al. Hematopoietic recostitution in a patient with Fanconi´s anemia by means of umbilical-cord blood from a HLA-identical sibling. New England Journal of Medicine, Waltham, v.321, p. 1174-1178, 1989.
GODOY, R. F. et al. Quantificação de subpopulações linfocitárias no sangue do cordão umbilical de eqüinos. Ciência Rural, v. 37, n. 3, p. 734-739, 2007.
GREENLEE, P. G. et al. Lymphomas in dogs: a morphologic, immunologic, and clinical study. Cancer, Philadephia,v.66, p.480-490, 1990.
GRINDEM, C. B. Blood cell markers. Veterinary Clinics of North America: Small Animal Practice, Philadelphia, v. 26, n. 5, p. 1043-1065, 1996.
HAMMOND, W. P. et al. A comparison of treatment of canine cyclic hematopoiesis with recombinant human granulocytemacrophage colony-stimulating factor (GM-CSF), G- CSF, interleukin-3, and canine G-CSF. Blood, v.76, n.3, p.523-532, 1990.
HAMMOND, W. P. et al. Chronic neutropenia. A new canine model induced by human granulocyte colony-stimulating factor. Journal of Clinical Investigation, v.87, n.2, p.704-710, 1991.
HARTNETT, B. J. et al. Transplantation of X-linked sever combined immunodeficient dogs with CD34+ bone marrow cells. Biology of Blood and Marrow Transplantation,
Charlottesville, v. 8, n. 4, p. 188-197, 2002.
HENRY, C. J. et al. Veterinary uses of recombinant human granulocyte colony- stimulating factor. Part I. Oncology. Compendium on Continuing Education for the Practicing Veterinarian, v.20, n.6, p.728-734, 1998.
HOLLAND, M. et al. Pancytopenia associated with administration of captopril to a dog. Journal of the American Veterinary Medical Association, v.208, n.10, p.1683-1686, 1996.
HORNING, S. J.; NADEMANEE, A.P. Autologous Hematopoietic Cell Transplantation for Non-Hodgin Lymphoma. In: THOMAS, E.D.; BLUME, K.G.; FORMAN, S.J.
Hematopoietic Cell Transplantation. Malden: Blackwell Science, 1999, cap. 80, p.939-951.
HOROWITZ, M. M. Uses and Growth of Hematopoietic Cell Transplantation. In: THOMAS, E.D.; BLUME, K.G.; FORMAN, S.J. Hematopoietic Cell Transplantation. Malden: Blackwell Science, 1999. cap. 2. p. 12-18.
HOSKINS, J. Confirmation needed for lymphoma. Biological & Agricultural DVM, v.32, p.16S-20S, 2001.
HUSS, R. et al. Evidence of peripheral blood-derived, plastic-adherent CD34 (-/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics. Stem Cells, Dayton, v. 18, n. 4, p. 252-260, 2000.
KITCHELL, B. E.; DHALIWAL, R. S. Hematology. Oncology, Imunology: CVT update: anticancer drugs and protocols using traditional drugs. In: KIRK, R. W.; BONAGURA, J. D., Current Veterinary Therapy XIII – Small Animal Practice. Philadelphia: Saunders, 2000. p. 465-473.
KORBLING, M. et al. Successful engraftment of blood derived normal hematopoietic stem cells in chronic myelogenous leukemia. Experimental Hematology, Washington, v. 9, 684-690, 1981.
KÖRBLING, M. et al. Allogeneic blood stem cell transplantation: peripheralization and yield of donor-derived primitive hematopoietic progenitor cells (CD34+ Thy-1dim) and
lymphoid subsets, and possible predictors of engraftment and graft-versus-host disease. Blood, v. 86, n. 7 p.2842-2848, 1995.
KÖRBLING, M.; ANDERLINI, P. Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter? Blood, v. 98, n. 10, p. 2900-2908, 2001.
KOVACIC, J. C. et al. Stem-cell therapy for myocardial diseases. Lancet, London, v. 363, n. 9422, p. 1735-1736, 2004.
LADIGES, W. C. et al. Canine models of bone marrow transplantation. Laboratory Animal Science, Memphis, v. 40, n. 1, p. 11-15, 1990.
LANORE, D.; DELPRAT, C. Quimioterapia Anticancerígena. São Paulo: Rocca, 2004. cap. 4, p. 53-78.
LU, L. et al. Stem cells from bone marrow, umbilical cord blood and peripheral blood for clinical application: current status and future application. Critical Reviews in Oncology/Hematology, Boca Raton, v.22, p.61-78, 1996.
LUCIDI, C. A.; TAKAHIRA,R. K. Uso do estimulante de colônia de granulócitos nas neutropenias em cães e gatos. Ciência Rural, Santa Maria, v.37, n.3, p.915-920, 2007.
MACEWEN, E. G.; YOUNG, K. M. Canine lymphoma and lymphoid leukemias. In: WITHROW, S. J.; MACEWEN, E. G. Small Animal Clinical Oncology, 2 ed. Philadelphia: W. B. Saunders Company, 1996. cap. 28 B, p. 451-479.
MAC VITTIE, T. J. et al. Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Physics, v.89, n.5, p.546-555, 2005.
MANGIERI, J. Síndromes paraneoplásicas. In: DALECK, C. R.; DE NARDI, A. B.; RODASKI, S. Oncologia em cães e gatos. São Paulo: Roca, 2008. Cap. 14, p. 237- 252
MASET, A. L. et al. O G-CSF na terapia do acidente vascular cerebral. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 31, n. 1, p.109-114 , 2009.
MATSUMURA, G. et al. First evidence that bone marrow cells contribute to the construction of tissue-engineered vascular autografts in vivo. Circulation, Baltimore, v. 108, n. 14, p. 1729-1734, 2003.
MCKENZIE, E. C., et al. Hematologic effects of subcutaneous administration of recombinant human granulocyte colony-stimulating factor (filgrastim) in healthy alpacas. American Journal Veterinary Research, United States, n. 6, v. 69, p. 770-776, 2008.
McSWEENEY, P. A. et al. Canine CD34: cloning of the cDNA and evaluation of an antiserum to recombinant protein. Blood, New York , v.88, n.6, p.1992-2003, 1996.
McSWEENEY, P. A. et al. Characterization of monoclonal antibodies that recognize canine CD34. Blood, New York, v.91,n.6, p.1977-86, 1998.
MENDRONE, JR A. et al. Factors affecting hematopoietic progenitor cell mobilization: an analysis of 307 patients. Transfusion and apheresis science, England, v. 39, n. 3, p. 187-192, 2008.
MORRISON, W. B. Lymphoma in Dogs and Cats. Jackson: Teton NewMedia, 2005. 124p.
MISHU, L. et al. Effects of recombinant canine granulocyte colony-stimulating factor on white blood cell production in clinically normal and neutropenic dogs. Journal of the American Veterinary Medical Association, v.200, n.12, p.1957-1964, 1992.
MOULTON, J. E. & HARVEY, J. W. Tumors of the lymphoid and hematopoietic tissues. In: MOULTON, J. E. Tumors in domestic animals. 3. ed. Berkeley: University of California Press, 1990. p. 231.
NAKAGE, A. P. M. et al. Metodologia e aplicação da citometria de fluxo na hematologia veterinária. Ciência Rural, Santa Maria, v. 35, n. 4, p. 966-973, jul-ago 2005.
NAKAGE, A. P. N. & SANTANA, A. E. Células-tronco hematopoéticas em cães. Ciência Rural. Santa Maria. v. 36, n. 1, p. 325-29, 2006.
NAKAGE, A. P. N. Et al. Quantificação de células CD34+ no sangue do cordão umbilical de cães. Ciência Rural. Santa Maria. V. 39, n. 2, p. 434-441, 2009.
NELSON, R. W.; COUTO, C. G. Medicina interna de pequenos animais. Rio de Janeiro: Elsevier, 2006, p. 1087-1096.
NIEMEYER, G. P. et al. Isolation and characterization of canine hematopoietic progenitor cells. Experimental Hematology, Amsterdam, v. 29, n. 6, p. 686-693, 2001.
NOTHDURFT, W. et al. Acceleration of hemopoietic recovery in dogs after extended- field partial-body irradiation by treatment with colony-stimulating factors: rhG-CSF and rhGM-CSF. International Journal of Radiation Oncology, Biology, Physics, v.37, n.5, p.1145-1154, 1997.
OBRADOVICH, J. E. et al. Evaluation of recombinant canine granulocyte colony- stimulating factor as an inducer of granulopoiesis. Journal of Veterinary Internal Medicine, v.5, n.2, p.75-79, 1991.
OBRADOVICH, J. E. et al. Effect of recombinant canine granulocyte colony-stimulating factor on peripheral blood neutrophil counts in normal cats. Journal of Veterinary Internal Medicine, v.7, n.2, p.65-67, 1993.
OGILVIE, G. K.; MOORE, A. S. Management of Specific Diseases: Clinical Briefing: Lymphoma. In: Managing the Veterinary Cancer Patient. Trenton: Veterinary Learning Systems, 1995. p. 228-259.
OGUMA, K. et al. In vitro effects of recombinant human granulocyte colony-stimulating factor on canine neutrophil apoptosis. Veterinary Immunology and Immunopathology, Amsterdam, v.108, n.3, p.307-314, 2005.
OKANO, A. et al. Predictive parameters for granulocyte colony-stimulating factor- induced peripheral blood stem cell mobilization. Journal of Clinical Apheresis, United States, n. 23, p. 171-177, 2008.
OWEN, L. TNM Classification of tumors in domestic animals. Geneva. World Health Organization, 1980; p. 46-47.
PHILLIPS, K. et al. FIV-infected cats respond to short-term rHuG-CSF treatment which results in anti-G-CSF neutralizing antibody production that inactivates drug activity. Veterinary Immunology and Immunopathology, Amsterdam, v.108, n.3, p.357-371, 2005.
RAMOS, R. S., et al. Estudo da prevalência das principais síndromes paraneoplásicas de 14 cães com linfoma- relato de casos. Veterinária e Zootecnia, supl. ao v. 15, n. 3, dez., p. 38-39, 2008.
RASKIN, R. E. In: RASKIN R. E.; MEYER, D. J. Atlas de citologia de cães e gatos, trad. FAGLIARI, J. J. Sao Paulo: Rocca, p.79-112, 2003.
RENAULT, M. A and LOSORDO, D. W. Therapeutic myocardial angiogenesis. Microvascular Research, United States, v. 74, n. 2-3, p. 159-171, 2007.
REVEL, T. et al. Effects of granulocyte colony-stimulating facto and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs. Blood, New York, v. 83, n. 12, p. 3795-3799, 1994.
REWERTS, J. M.; HENRY, C. J. Veterinary uses of recombinant human granulocyte colony-stimulating factor. Part II. Infectious Diseases. Compendium on Continuing Education for the Practicing Veterinarian, v.20, n.7, p.823-827, 1998.
RICHMAN, C. M. et al. Purification and characterization of granulocytic progenitor cells (CFU-C) from human peripheral blood using immunologic surface markers. Blood, New York, v. 51, n.1, p.1-8, 1978.
RODASK, S.; DE NARDI, A. B. Quimioterapia Antineoplásica em cães e gatos. São Paulo: MedVet Livros, 2008.
ROITT, I.; BROSTOFF, J.; MALE, D. Imunologia. Sao Paulo: Manole, 2003. 481p.
SANDMAIER, B. M. et al. Allogeneic transplants of canine peripheral blood stem cells mobilized by recombinant canine hematopoietic growth factors. Blood, New York, v. 87, n. 8, p. 3508-3513, 1996.
SANTANA, A. E. Benzenismo experimental: desenvolvimento da medula óssea ectópica. Ribeirão Preto, 1988, Tese (doutorado em fisiologia) Faculdade de medicina de Ribeirão Preto, Universidade de São Paulo.
SCHÄBITZ, W. R. et al. Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia. Stroke. v. 34, n. 3, p. 745-751, 2003.
SIENA, S. et al. Circulation of CD34+ hematopoietic stem cells in the peripheral blood of
high-dose cyclophosphamide-treated patients: enhancement by intravenous recombinant human granulocyte-macrophage colony-stimulating factor. Blood, New York, v. 74, n. 6, p. 1905-1914, 1989.
SIX, I., et al. Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia. European Journal of Pharmacology, Netherlands, v. 458, n. 3, p. 327-328, 2003.
SKIPPER H. E., SCHABEL F. M. J. R.: Tumor cell heterogeneity: implications with respect to classification of cancer by chemotherapeutic effect. Cancer Treatment
Reports, United States, v. 68, n. 1, p. 43-61, 1984.
SOLÁ, C. et al. Bone marrow transplantation: Prognostic factors of pheripheral blood stem cell mobilization with cyclophosphamide and filgrastim (r-metHuG-CSF): The CD34+ cell dose positively affects the time to hematopoietic recovery and supportive
requirements after high-dose chemotherapy. Hematology, v. 4, n. 3, p. 195-209, 1999.
SOZMEN, M. et al. Use of fine needle aspirates and flow cytometry for the diagnosis, classification, and immunophenotyping of canine lymphomas. Journal of Veterinary Diagnostic Investigation, v.17, p. 323-329, 2005.
STORB, R. et al. DLA-identical bone marrow grafts after lowdose total body irradiation: the effect of canine recombinant hematopoietic growth factors. Blood, v.84, n.10, p.3558-3566, 1994.
STORB, R. Allogenic hematopoietic stem cell transplantation – Yesterday, today, and tomorrow. Experimental Hematology, Amsterdam, v.31, p.1-10, 2003.
SUEIRO, F. A. R. et al., Canine lymphomas: a morphological and immunohistochemical study of 55 cases, with observations on p53 immunoexpression. Journal of Comparative Pathology, Edinburgh, v. 131, p.207-213, 2004.
SUTHERLAND, D. R. et al. The ISHAGE guidelines for CD34+ cell determination by flow cytometry. International Society of Hematotherapy and Graft Engineering. Journal of Hematotherapy, New York, v. 5, n. 3, p. 213-226, 1996.
THOMAS, E. D. Historical Review: a history of haemopoietic cell transplantation. British Journal of Haematology, Oxford, v.105, p.330-339, 1999.
THOMAS, E. D.; STORB, R. The Development of Scientific Foundation of Hematopoietic Cell Transplantation Based on Animal and Human Studies. In: THOMAS, E.D.; BLUME, K.G.; FORMAN, S.J. Hematopoietic Cell Transplantation. Malden: Blackwell Science, 1999. cap. 1. p.1-11.
THOMASSON, B. et al. Direct comparison of steady-state marrow, primed marrow, and mobilized peripheral blood for transduction of hematopoietic stem cells in dogs. Human Gene Therapy, v.14, n.17, p.1683-1686, 2003.
WAGNER, J. L. & STORB, R. Preclinical large animal models for hematopoetic stem cell transplantation. Current Opinion in Hematology, Philadelphia, v.3, n.6, p.410, 1996.
VAIL, D. M.; OGILVIE, G. K. Neoplasias Linfóides. In: BICHARD, S. J.; SHERDING, R. G. Manual Saunders – Clínica de Pequenos Animais. São Paulo: Roca, 1998. cap. 6, p. 218-225.
VAIL, D. M.; YOUNG, K. M. Canine Lymphoma and Lymphoid Leukemia. In: WITHROW, S. J.; VAIL, D. M. Withrow & MacEwen´s Small Animal Clinical Oncology. 4. ed. St. Louis: Saunders Elsevier, 2007. cap. 31. p. 699-769.
APÊNDICES
APÊNDICE A: Valores de referência para hemograma de cães. Jaboticabal, 2010.
PARÂMETRO VALOR Hemácias (x106/µL) 5,5 – 8,0 Hemoglobina (g/dL) 12,0 – 18,0 Hematócrito (%) 37 - 55 VCM (fL) 60 - 77 CHCM (g/dL) 31 - 34 Plaquetas (x103/µL) 180 - 400 Leucócitos (x103/µL) 0-18 Basófilos (céls/µL) 0 Eosinófilos (céls/µL) 120 – 1800 Bastonetes (céls/µL) 0 - 500 Segmentados (céls/µL) 3600 - 13800 Linfócitos (céls/µL) 720 - 5400 Monócitos (céls/µL) 180 - 1800
Fonte: LPCV - Hospital Veterinário da FCAV/UNESPJaboticabal.
APÊNDICE B: Valores de referência para contagens totais de leucócitos e fórmulas leucocitárias relativa e absoluta. Jaboticabal, 2010.
PARÃMETROS