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Gene mutation, DNA repair and transposition

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Gene mutation, DNA repair and

transposition

Prof. Dr. İsmail AKYOL Prof. Dr. M. Ali YILDIZ Prof. Dr. M. Muhip ÖZKAN

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Outline of course

• Mutations comprise any change in the nucleotide sequence of an organism’s genome.

• Mutations comprise any change in the nucleotide sequence of an organism’s genome.

• Mutations are a source of genetic variation and provide the raw material for natural selection.

• Mutations have a wide range of effects on organisms depending on the type of base-pair alteration, the location of the mutation within the

chromosome, and the function of the affected gene product.

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Outline of course

• Single-gene mutations cause a wide variety of human

diseases.

• Organisms rely on a number of DNA repair mechanisms to

counteract mutations.

• Mutations in genes whose products control DNA repair

lead to genome hypermutability, human DNA repair

diseases, and cancers.

• Transposable elements may move into and out of

chromosomes, causing chromosome breaks and inducing

mutations both within coding regions and in

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