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Mechanisms of Antimicrobial

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(1)

Mechanisms of Antimicrobial

Resistance in Bacteria And

(2)

Effects of Antibiotics on Bacteria

(3)

Bacteriostatic effect  Penicillin  Kinolons  Aminoglycosides  Bactericidal effect  Erythromycin  Clindamycin  Tetracyclines  Sulfonamides  Chloramphenicol

(4)

1- Prevent to cell wall synthesis (Penicillins)

2-Influencing to cytoplasmic membrane (polymyxin) 3- Prevent to protein synthesis (tetracycline,

gentamicin, macrolides)

4- Influencing to nucleic acid function and synthesis (quinolones)

(5)

Effects to ribosamal activity Aminoglycosides Chloramphenicol Macrolides Lincosamides Tetracyclines Ribozom DNA Inhibition of Nucleic acid synthesis Quinolones Rifampin Nitrofurans

Inhibition of DNA synthesis

Sulfonamides Trimethoprim Ormethoprim Effects to cell membrane polymyxins

Inhibition of cell wall synthesis

Beta Lactams Bacitracin

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