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(NSAIDs)-I NonsteroidalAnti-inflammatory Drugs

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(1)

Nonsteroidal

Anti-inflammatory Drugs

(NSAIDs) - I

INTRODUCTION TO

(2)

Nonsteroidal anti-inflammatory

drugs (NSAIDs) are

usually

used for

•

reduce pain

•

decrease fever

(3)
(4)
(5)

•

The salicylates are derivatives of

2-hydroxybenzoic acid (salicylic

acid).

(6)

SALICYLIC ACID DERIVATIVES

SALICYLIC ACID

O H

(o-Hydroxy benzoic acid)

(7)

Dietylamine Salicylate C O O H O H H N (C2H5)2 . Salicylamide O H C O N H2 Phenyl Salicylate C O O O H Sodyum Salicylate C O O N a O H

(8)

Acetylsalicylic Asid

ASPİRİN

O C O C H3

(9)

O H C O O H (C H3C O )2O 2 H S O 4 O C O C H3 C O O H + C H3C O O H

Synthesis of Aspirin

(10)

Calcium Acetyl Salisylate

Aluminum Acetyl Salisylate

O C O C H3 C O O - 2 C a O C O C H3 C O O - 2 A lO H

(11)

Sulfasalazine

(12)

Diflunisal

HO

HOOC

F

F

(13)

ANILIN and p-AMINOPHENOL

DERIVATIVES

(14)
(15)

Phenacetin

N H C O C H

3

C

2

H

5

O

(16)

Acetaminophen (Paracetamol)

O H

N H C O C H

3

(17)
(18)
(19)

N O H3C N

H3C

Antipyrine

(

Phenazone)

(20)

N O H3C N H3C O H C O O H

Antipyrine Salicylate

(21)

Aminopyrine

N

H

3

C

N

O

H

3

C

N

C H

3

C H

3 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazoline-5-one

(22)

Dipyrone

(

Metamizole )

NOVALGİN N H3C N O H3C N C H3 C H2S O3N a

1) Sodium 1-phenyl-2,3-dimethyl-3-

pyrazoline

-5-oxo-4-methylamino-methanesulphonate

(23)
(24)

4-Butyl-1,2-diphenyl-pyrazolidine-3,5-dione

(25)

Oxyphenbutazone

(RS)-4-butyl-1-(4-hydroxyphenyl)-2-phenylpyrazolidine-3,5-dione

(26)

Sulfinpyrazone

1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione

(27)

Apazone

5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine -1,3-dione

(28)

Proquazone

Referanslar

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