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CANCER CELL

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(1)

BIO 478

CANCER CELL

(2)

Tumor Angiogenesis

• The tumor cannot metastasize without vascularization.

• Angiogenesis is sufficient for the tumor's biological metastasis relationship.

(3)

Steps of Tumor Angiogenesis

(4)

• Capillary budding by proteolytic cleavage of the main vessel basement membrane

• Endothelial cell migration from original capillaries with angiogenic stimulation

• Endothelial cell proliferation

• Endothelial cell maturation with growth inhibition and organization into the capillary tube

(5)

• vascular silence phase

• molecular mechanism of angiogenic switch

(6)

• Various factors that stimulate angiogenesis - Vascular endothelial growth factor (VEGF)

- Basic fibroblast growth factor (bFGF)

(7)

• Revascularization has a double effect on tumor growth…

• Angiogenesis is not only for tumor growth, but also necessary for metastasis.

(8)

• Proteases are also effective in regulating the balance between angiogenic and

antiangiogenic factors.

- basic fibroblast growth factor - plasmin

Referanslar

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