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飲水是對人類暴露到這些藥物的主要來 源

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• 計畫中文名稱 自來水淨水程序對酸性藥物處理效能評估

• 計畫英文名稱 Acid Pharmaceutical Removal in Drinking Water Treatment Process

• 系統編號 PB9709-0717 • 研究性質 應用研究

• 計畫編號 NSC97-2221-E038-005 • 研究方式 學術補助

• 主管機關 行政院國家科學委員會 • 研究期間 9708 ~ 9807

• 執行機構 臺北醫學大學公共衛生學系

• 年度 97 年 • 研究經費 639 千元

• 研究領域 環保工程

• 研究人員 胡景堯

• 中文關鍵字 酸性藥物;混凝;過濾;加氯消毒;減弱式全反射-傅立葉轉換紅外線光譜儀(ATR-FTIR);液相層析串聯質譜儀(LC/MS/MS)

• 英文關鍵字 Acid pharmaceuticals; coagulation; filtration; chlorination; ATR-FTIR;LC/MS/MS

• 中文摘要

近年來許多酸性藥物已經被發現存在於環境中,而相關研究證實,有些藥物會對人 體或其他生物造成危害。飲水是對人類暴露到這些藥物的主要來 源。要評估這些藥物對 人類的健康風險,必須先瞭解淨水程序對這些藥物的去除效率。本研究計畫分別探討淨 水程序中混凝、過濾及加氯消毒等單 元對diclofenac, ibuprofen, naproxen 及 ketoprofen 等 四種酸性藥物的去除效果,並探討不同淨水單元配置組合對整個淨水程序對酸性藥物的 去除效 果的影響。另外本研究還計畫以減弱式全反射-傅立葉轉換紅外線光譜儀 (Attenuated Total. Reflectance- Fourier Transform Infrared. Spectrometer, ATR- FTIR)分析不 同藥物與吸附劑之間的吸附機制。各種酸性藥物的濃度及加氯消毒後的副產物則將以液 相層析串聯質譜儀(Liquid chromatography tandem mass spectrometry, LC/MS/MS)進行 分析。

• 英文摘要

Acid pharmaceuticals have been widely found in the environment. They may be toxic for human and aquatic species. Drinking is the most important access of acid pharmaceuticals exposure for human. To access the health risk of the acid pharmaceuticals for human, the removal of acid pharmaceuticals in drinking water treatment process have to be investigated. This study will examine the removal of four acid pharmaceuticals, diclofenac, ibuprofen, naproxen and ketoprofen in coagulation, filtration and chlorination unit, respectively. The combination removal of acid pharmaceuticals in whole drinking water treatment process and the effects of the arrangement of the units will also be investigated. An attenuated total reflectance-Fourier transform infrared spectrometer (ATR- FTIR) will be used to characterize the bonding of the adsorbents and the surface of metal hydroxides. The concentration of the acid pharmaceuticals and the types of the by-products of chlorination will be determined by a liquid chromatography tandem mass spectrometry (LC/MS/MS).

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