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21世紀醫學新希望:黃繼賢

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二十一世紀醫學新希望心得 b303097110 黃繼賢

醫學越進步,對病患的保障就越大,許多在以前是不可能完成的任務和無法達 成的技術,經由醫藥學界的努力之下,頗有嶄獲,值得嘉許

(1)New Direction in Ophthalmology:視網膜開刀用更精湛雷射方式減少誤差 (2)Innovative Heart Research:

治療心臟疾病可以用細導管伸入治療,較以前傳統動刀會大量失血方式好

組織培養從只能培養2 維平層心肌細胞到 3 維管狀的心肌細胞是一大突破

(2-1)傳統心肌梗塞的病人用骨骼肌去做替換而產生結痂是日後的病根 (2-2)較新:胚胎幹細胞(endothelial vessel networks)培養 2 維平層心肌細胞 (2-3)更新:含 endothelial vessel networks 幹細胞培養 vasculization 心肌細胞 Step1:底層的心肌細胞先長

Step2:需有 scaffold 誘導基質

Step3:在具有 laminin(degradable)包覆的 PDMS 表面生長:當 laminin degrade 時, 附著的心肌跟隨著線狀包覆而形成管狀

(3)New Strategies in Fighting Cancer: targeting on cancer cell

(3-1)傳統:化療藥物無法選擇性作用於癌細胞,所以副作用非常多 (3-2)較新:選擇性作用於某些受器

VEGF 選擇性抑制劑(抑制血管新生) Bevacizumab (Avastin)

EGFR 選擇性抑制劑 Cetuximab (Erbitux)/ Gefitinib (Iressa). Proteasome 選擇性抑制劑 Bortezomib (Velcade).

HER2 選擇性抑制劑 Trastuzumab(Herceptin)

(3-3)更新:

carbon nanotubes 有 glycopolymer 膜衣 沒有細胞生長抑制效果

carbon nanotubes 無 glycopolymer 膜衣 抑制正常細胞及腫瘤細胞生長

carbon nanotubes 有 glycopolymer 膜衣 且有snail protein

選擇性作用於腫瘤細胞 抑制腫瘤細胞生長 (4)New Dimensions Brain Research:

在帕金森氏症,阿茲罕默症的研究上都有更進一步的突破,做更深一層各種腦 疾病的研究 Reference: http://www.nanotechbuzz.com/50226711/snail_protein_may_help_nanotubes_target_ cancer_cells.php http://www.redorbit.com/news/health/158911/new_oncology_strategy_molecular_tar geting_of_cancer_cells/index.html

Tissue Engineering of Vascularized Cardiac Muscle From Human Embryonic Stem Cells

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