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Correlation between joint [F-18] FDG PET uptake and synovial TNF-alpha concentration: a study with two rabbit models of acute inflammatory arthritis.

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Correlation between joint [F-18] FDG PET uptake and

synovial TNF-alpha concentration: a study with two

rabbit models of acute inflammatory arthritis.

潘力誠

Lin P.-W;Liu R.-S;Liou T.-H;Pan L.-C;Chen C.-H

Abstract

Appl Radiat Isot. 2007 Nov;65(11):1221-6. Epub 2007 Jun 30.

Correlation between joint [F-18] FDG PET uptake and synovial TNF-alpha concentration: a study with two rabbit models of acute inflammatory arthritis. Lin PW, Liu RS, Liou TH, Pan LC, Chen CH.

Department of Physical Medicine and Rehabilitation, Taipei Medical University-Wan Fang Hospital, 111 Hsing-Long Road Sec. 3, Taipei 11696, Taiwan.

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-alpha concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-alpha measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-alpha ratios. An equation to estimate the TNF-alpha ratio from a MSUV was also derived.

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