• Sonuç bulunamadı

Abeta Aggregation inhibitors. Part I: Synthesis and biological activity of phenylazo benzenesulfonamides

N/A
N/A
Info
İndir
Protected

Academic year: 2021

Share "Abeta Aggregation inhibitors. Part I: Synthesis and biological activity of phenylazo benzenesulfonamides"

Copied!
1
0
0

Yükleniyor.... (view fulltext now)

Şimdi indir ( 1 sayfa )

Tam metin

(1)

Abeta Aggregation inhibitors. Part I: Synthesis and

biological activity of phenylazo benzenesulfonamides

楊禮明;林淑娟

Lin SJ;Shiao YJ;Chi CW;Yang LM

Abstract

Phenylazo benzenesulfonamides were designed and synthesized as beta-amyloid (Abeta40) fibril assembly inhibitors, and evaluated for inhibition of Abeta40 aggregation and neurotoxicity using rat cortical neurons. Compound 2 (LB-152) was the most potent compound in this study, and the para-NMe(2) group on the end of the phenylazo moiety may play an important role in preventing Abeta40 fibril formation. LB-152 provides a new lead for further development of potential beta-amyloid aggregation inhibitors to treat AD.

Referanslar

Şimdi indir ( PDF - 1 sayfa - 34.54 KB )

Benzer Belgeler

Clopidogrel and morphine: Aggregation disturbance?

The PCS panel would use the following criteria to deter- mine whether compensation can be granted: “Medical injury” means a personal injury or wrongful death due to medical

Aggregation of lipoprotein(a) to apoli-poprotein A-I and coronary artery problem

We appreciated to learn the comment by Wiwanitkit to our prospec- tive population-based study published in September issue of The Anatolian Journal of Cardiology 2013; 13: 543-51

Bir şaheser!

Aynı zamanda münekkit olan Nahit B., kendisinin de tenkit edileceğini ildiği için küçük hikâyedeki bütün usul ve kaidelere riayet etmiştir. Fâkat, ne olurdu

Kortikal Hassas Bölge Tümörlerinde Uyanık Kraniyotomi ve Vakalar ile Klinik Tecrübemiz

Vaka sunuları kısmında ise kliniğimizde UK uygulanan 4 hastanın demografik özellikleri, ameliyat öncesi ve sonrası radyoloji, patoloji verileri ve ilgili klinik

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors

Four different cancer cell lines, namely, prostate adenocarcinoma (PC-3), colon carcinoma (HCT-116), human breast cancer (T47D), breast carcinoma (MCF7) and a normal human

Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors

Synthesis, biological evaluation and molecular docking studies of novel 1,3,4-oxadiazole derivatives possesing benzotriazole moiety as FAK inhibitors with anticancer

Comparison of the relative activities of a-tocopherol and pmc on platelet aggregation and antioxidative activity.

The concentration of PMC resulting in a decrease of 0.20 in the absorbance of DPPH was about 12.1+/-3.6 microM, was comparable in potency to alpha-tocopherol,