Letter to the editor: Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model

(1)

Elif Bolat et al.

540 Asian Spine J 2014;8(4):540-540

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Asian Spine Journal • pISSN 1976-1902 eISSN 1976-7846 • www.asianspinejournal.org

Received Jun 13, 2014; Accepted Jun 13, 2014 Corresponding author: Mevci Ozdemir

Department of Neurosurgery, Pamukkale University School of Medicine, 20070, Kinikli, Denizli, Turkey Tel: +90-258-444-0728, Fax: +90-258-213-4922, E-mail: drmevci@hotmail.com

Letter to the Editor: Investigation of Efficacy of

Mitomycin-C, Sodium Hyaluronate and Human

Amniotic Fluid in Preventing Epidural Fibrosis and

Adhesion Using a Rat Laminectomy Model

Elif Bolat

1

_{, Erdoğan Kocamaz}

2

_{, Zeki Kulahcilar}

3

_{, Ali Yilmaz}

1

_,

Abdullah Topcu

4

_{, Mevci Ozdemir}

4

_{, Mehmet Erdal Coskun}

4

1_{Department of Neurosurgery, Dogubeyazıt State Hospital, Agrı, Turkey}

2_{Department of Histology and Embryology, Pamukkale University, School of Medicine, Denizli, Turkey} 3_{Department of Neurosurgery, Fatsa Cinar Hospital, Ordu, Turkey}

4_{Department of Neurosurgery, Pamukkale University School of Medicine, Denizli, Turkey}

Letter to the Editor Asian Spine J 2014;8(4):540 • http://dx.doi.org/10.4184/asj.2014.8.4.540

ASJ

A

S

J

Asian Spine Journal

The article entitled “Investigation of Efficacy of Mitomy-cin-C, Sodium Hyaluronate and Human Amniotic Fluid in Preventing Epidural Fibrosis and Adhesion Using a Rat Laminectomy Model” published in the Asian Spine Jour-nal highlights an important problem for spiJour-nal surgeons [1]. We are thankful to the authors for their comments and informative letter, which highlights the doses which might be helpful in further research. The authors are right because using different dissolving methods can affect the results, but we didn’t add any dissolving solution. Regard-ing the second point about dosage and density, we used a 0.01% mitomycin C solution [2] (an instant preparation that is usually used for ophthalmologic disorders) and 0.1 mL sodium hyaluronate [3]. Referring to the last question about the duration time, all of the drugs were applied 3 minutes. We hope those information are helpful and may encourage further research.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

References

1. Bolat E, Kocamaz E, Kulahcilar Z, et al. Investigation of efficacy of mitomycin-C, sodium hyaluronate and human amniotic fluid in preventing epidural fibrosis and adhesion using a rat laminectomy model. Asian Spine J 2013;7:253-9.

2. McEvoy GK. AHFS Drug information 2000: Bethes-da, MD: American Society of Health-System Phar-macists; 2000. p.1019-21.

3. Massie JB, Schimizzi AL, Huang B, Kim CW, Garfin SR, Akeson WH. Topical high molecular weight hy-aluronan reduces radicular pain post laminectomy in a rat model. Spine J 2005;5:494-502.