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Induced Pluripotent Stem Cells

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(1)

Induced Pluripotent Stem Cells

Dr. Açelya Yilmazer

(2)

2006, Yamanaka: “introduction of a small set of transcription factors into a differentiated cell was sufficient to revert the cell to a pluripotent state”

Oct3/4 Sox2

Klf4 cMyc

Takahashi &Yamanaka 2006

(3)

iPS Cells

Cardiomyocytes Hepatocytes Somatic Cells

Patient

What do iPS cells offer?

Disease modelling Drug-screening

Neurons

Regenerative medicine

www.nobelprize.org

(4)

The Reprograming Menu

Gonzalez et al., 2011

(5)

iPS Cell Technology

Inoue et al.2014, THE EMBO JURNAL

(6)

Limitations Limitations

Main obstacles for clinical translation of

reprogrammed somatic cells to a pluripotent state by the forced expression of specific transcription factors are:

 the limited efficiency of reprogramming methodologies

 long-term culture conditions

 the safety of induced pluripotent stem (iPS)

cells that may lead to spontaneous formation of teratomas on implantation

Referanslar

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