中華民國兒童胸腔醫學會論文摘要
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1.本格式請用中文（標楷體 10 號字體或以上）或英文（Times New Roman 10 號 字體或以上）打字，請勿超出框線外。 2.第一著者即演講者。 3.摘要內容包括研究目的、方法、結果和結論。 4.每一段第一行應凹進二字，行與行間不空行（段與段間可空一行），左邊行首請齊 頭。 5.來件請附有簽名原稿及電子檔。 6.稿件請寄回學會。學會地址：403 台中市西區中港路一段 23 號 e-mail：pedipulm@ms67.hinet.net 中 文 標 題 ：Captopril 降低呼吸器導致肺傷害老鼠的纖溶酶原激活物抑制物的活性 著 者 （ 中 文 ） ：陳中明、汪棱芳、周琇珠 所 屬 機 構 （ 中 文 ） ： 臺北醫學大學小兒科、生化科、解剖科
英 文 標 題 ：Captopril decreases plasminogen activator inhibitor activity in rats with ventilator-induced lung injury
著 者 （ 英 文 ） ：Chung-Ming Chen, Leng-Fang Wang, Hsiu-Chu Chou
所 屬 機 構 ：Department of Pediatrics, Biochemistry, and Anatomy, Taipei Medical University.
Captopril decreases plasminogen activator inhibitor activity in rats with ventilator-induced lung injury
陳中明、汪棱芳、周琇珠
臺北醫學大學小兒科、生化科、解剖科
Chung-Ming Chen, Leng-Fang Wang, Hsiu-Chu Chou
Department of Pediatrics, Biochemistry, and Anatomy, Taipei Medical University, Taipei, Taiwan
Objective: To test the hypothesis that high tidal-volume ventilation increases plasminogen
activator inhibitor (PAI)-1 and captopril (CAP) may attenuate this effect.
Interventions: Adult male Sprague-Dawley rats were randomized to receive 1) HVZP
(high-volume zero PEEP) group at a tidal volume of 40 mL/kg, a respiratory rate of 25 breaths/min, and a FiO2 of 0.21, or 2) HVZP+CAP (captopril) group received CAP (100
mg/kg, ip) 30 min before the HVZP ventilation. Another group that did not receive ventilation served as the control.
Measurements and main results: Total protein recovered from brobchoalveolar lavage
fluid was significantly higher in rats ventilated with HVZP protocols than in control rats. Rats treated with HVZP ventilation had significantly higher lung angiotensin (ANG) II and plasma active PAI-1 levels than did the control and HVZP+CAP groups. Lung ANG II levels correlated positively with plasma PAI-1. HVZP and HVZP+CAP groups had significantly higher lung injury score than did the control group and rats treated with HVZP+CAP ventilation exhibited significantly lower lung injury score than did the HVZP group.
Conclusion:Mechanical ventilation with high tidal volume and no PEEP increases alveolar fibrin deposition and suppresses systemic fbrinolytic activity, which are attenuated by angiotensin converting enzyme inhibitor captopril.
